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Effect of MgSO4, L-DOPA, and haloperidol on delayed stereotyped behavior caused by hyperactivation of the sensorimotor cortex in rats

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Repeated rhythmical electrostimulation of the right sensorimotor cortex resulted in persistent psychoaffective disorders and locomotor stereotypy in rats. Intraperitoneal or intrastriatal administration of MgSO4 did not prevent stereotyped behavior. The animals with developed syndrome exhibited sharply enhanced behavioral responses to L-DOPA and weakened cataleptic reactions to haloperidol and showed psychoaffective disorders in response to MgSO4 administration. It is suggested that dopaminergic hyperactivity and NMDA glutamate receptors are involved in the realization of delayed stereotyped behavior.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    V. K. Lutsenko & N. N. Khlebnikova

Authors
  1. V. K. Lutsenko
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  2. N. N. Khlebnikova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 294–298, September, 1999

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Lutsenko, V.K., Khlebnikova, N.N. Effect of MgSO4, L-DOPA, and haloperidol on delayed stereotyped behavior caused by hyperactivation of the sensorimotor cortex in rats. Bull Exp Biol Med 128, 913–916 (1999). https://doi.org/10.1007/BF02438083

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  • DOI: https://doi.org/10.1007/BF02438083

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