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Genetic mechanisms of the involvement of SMP-69 protein in memory consolidation

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Intracerebral administration of antibodies to SMP-69 protein to rats 24 h prior to passive avoidance conditioning impaired memory processes, while the administration 48 h after learning had no such effect. Activation of RNA and protein synthesis was observed 24 h after the administration. It is suggested that the impaired consolidation of memory traces is due to the synthesis of “anticonsolidation” proteins.

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Authors and Affiliations

  1. A. I. Karaev Institute of Physiology, Azerbaijan Academy of Sciences, Baku

    A. A. Mekhtiev

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  1. A. A. Mekhtiev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 141–143, August, 1999

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Mekhtiev, A.A. Genetic mechanisms of the involvement of SMP-69 protein in memory consolidation. Bull Exp Biol Med 128, 779–781 (1999). https://doi.org/10.1007/BF02433813

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  • DOI: https://doi.org/10.1007/BF02433813

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