Skip to main content
SpringerLink
Log in

Energy, structure, conformation, and heart failure

  • Reviews
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The problem of heart failure is analyzed from the point of view of conformation changes in submolecular cardiomyocyte structures. The development of heart failure as a consequence of abnormal function of contractile myocardial proteins is discussed. The properties of actin and the role of structural changes in actin molecules in the impairment of ATP energy utilization and generation of contractile force by actomyosin complexes are studied. Experiments on animal models and autopsy samples showed that conformation changes precede disturbances in energy utilization by myofibrils, abnormal functioning of the energy-producing and Ca2+-transporting systems during the development of heart failure. It is proposed that rigid recombinations of submolecular structures in contracile proteins underlie impairment of myocardial contractility and resistance of the myocardium to regulatory factors and drugs (immobilization).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. V. Andreev and M. V. Sokolov,Modeling of Diseases [in Russian], Moscow (1973).

  2. V. Kh. Vasilenko, S. B. Fel'dman, and N. K. Khitrov,Myocardiodystrophy [in Russian], Moscow (1989).

  3. A. P. Demchenko,Luminescence and Dynamics of Protein Structure [in Russian], Kiev (1988).

  4. V. I. Kandror,Physiology of Circulation. Physiology of the Heart [in Russian], Leningrad (1980).

  5. V. I. Kapel'ko,Byull. Vsesoyuz. Kardiol. Nauch. Tsentra, No. 1, 103–110 (1981).

    Google Scholar 

  6. N. V. Karsanov,Arterial Hypertension and Heart Failure [in Russian], Tbilisi (1971), pp. 109–111.

  7. N. V. Karsnov,Vopr. Med. Biol. Farm. Khimii, No. 2, 13–16 (1999).

    Google Scholar 

  8. N. V. Karsanov and B. G. Dzhinchvelashvili,Izv. Akad. Nauk GSSR. Ser. Biol., No. 2, 134–142 (1988).

    Google Scholar 

  9. N. V. Karsanov, R. V. Kapanidze, and N. V. Khaindrava, —Ibid., No. 13, 270–279 (1987).

    Google Scholar 

  10. N. V. Karsanov, V. A. Magaldadze, T. N. Macharashvili,et al., Vestn. Akad. Med. Nauk SSSR, No. 12, 60–68 (1988).

    PubMed  Google Scholar 

  11. N. V. Karsanov, T. N. Macharashvili, and V. A. Magaldadze,Byull. Eksp. Biol. Med.,111, No. 5, 534–536 (1991).

    CAS  Google Scholar 

  12. N. V. Karsanov, N. O. Melashvili, Z. G. Khugashvili,et al., Kardiologiya, No. 2, 82–86 (1990).

    Google Scholar 

  13. N. V. Karsanov and T. G. Samsonidze,Biofizika, No. 1, 7–9 (1986).

    Google Scholar 

  14. N. V. Karsanov, G. V. Sukoyan, I. K. Dzhibgashvili,et al., Pat. Fiziol., No. 3, 3–8 (1999).

    Google Scholar 

  15. N. V. Karsanov, G. V. Sukoyan, N. N. Kipshidze,et al., Klin. Eksp. Farmakol., No. 3, 28–33 (1996).

    Google Scholar 

  16. N. V. Karsanov, G. V. Sukoyan, D. R. Tatulashvili,et al., Pat. Fiziol., No. 3, 5–9 (1993).

    Google Scholar 

  17. N. V. Karsanov, G. V. Sukoyan, D. R. Tatulashvili,et al., Vopr. Narkol., No. 4, 48–52 (1995).

    Google Scholar 

  18. N. V. Karsanov, G. V. Sukoyan, D. R. Tatulashvili, and N. E. Guledani,Vopr. Med. Biol. Farm. Khimii, No. 2, 36–40 (1999).

    Google Scholar 

  19. N. V. Karsanov, G. V. Sukoyan, E. V. Yarovaya,et al., Vorp. Narkol., No. 3, 36–41 (1995)

    Google Scholar 

  20. N. V. Karsanov, D. R. Tatulashvili, and G. V. Sukoyan,Izv. Akad. Nauk GSSR. Ser. Biol., No. 4, 271–283 (1990).

    Google Scholar 

  21. N. V. Karsanov, D. R. Tatulashvili, G. V. Sukoyan, and L. T. Kuchava,Vopr. Med. Khimii, No. 6, 42–47 (1993).

    Google Scholar 

  22. N. V. Karsanov, D. R. Tatulashvili, G. V. Sukoyan, and L. T. Kuchava,Vopr. Med. Biol. Farm. Khimii, No. 2, 40–45 (1999).

    Google Scholar 

  23. N. V. Karsanov, Z. N. Khugashvili, L. D. Mamulashvili,et al., Kardiologiya, No. 1, 80–89 (1984).

    Google Scholar 

  24. N. V. Karsanov, Z. N. Khugashvili, L. D. Mamulashvili, and E. I. Guchua,Izv. Akad. Nauk GSSR. Ser. Biol., No. 6, 393–398 (1992).

    Google Scholar 

  25. N. V. Karsanov, Z. N. Khugashvili, N. O. Edisherashvili, and R. V. Uzunyan, —Ibid., No. 5, 468–490 (1981).

    Google Scholar 

  26. N. V. Karsanov and D. D. Eristavi,Biofizika, No. 5, 748–751 (1983).

    Google Scholar 

  27. A. P. Kitaeva, and N. V. Karsanov,Byull. Eksp. Biol. Med.,128, No. 7, 35–38 (1999).

    CAS  Google Scholar 

  28. A. P. Kitaeva, Z. D. Tedeeva, and N. V. Karsanov, —Ibid., No. 7, pp. 182–185.

    Google Scholar 

  29. G. F. Lang,Problems of Circulatory Pathology and Clinical Features of Cardiovascular Diseases [in Russian], Leningrad (1936).

  30. D. I. Levitskii,Uspekhi Biol. Khimii,27, 74–101 (1986).

    Google Scholar 

  31. V. V. Lednev,Structural Bases and Regulation of Biological Mobility [in Russian], Moscow (1980), pp. 221–270.

  32. V. Raab,Advances in Cardiology [in Russian], Ed. R. Kheglin, Moscow (1959), pp. 67–140.

  33. T. G. Samsonidze, D. D. Eristavi, and N. V. Karsanov,Byull. Eksp. Biol. Med.,127, No. 1, 101–105 (1999).

    CAS  Google Scholar 

  34. D. S. Sarkisov,Essays on History of General Pathology [in Russian], Moscow (1993).

  35. G. V. Sukoyan, D. R. Tatulashvili, N. V. Karsanov,Byull. Eksp. Biol. Med.,127, No. 4, 395–399 (1999).

    Google Scholar 

  36. N. K. Furkalo, V. V. Bratus', and R. A. Frol'kis,Coronary Insufficiency: Blood Supply, Function, and Metabolism of Myocardium [in Russian], Kiev (1986).

  37. M. M. Khananashvili, N. V. Karsanov, G. V. Sukoyan,et al., Fiziol. Zh. SSSR, No. 12, 39–49 (1992).

    Google Scholar 

  38. A. Khekht,Introduction into Experimental Bases of Modern Myocardial Pathology [in Russian], Moscow (1975).

  39. Yu. G. Tsellarius and L. G. Semenova,Histophathology of Focal Metabolic Damages to Myocardium [in Russian], Novosibirsk (1972), p. 209.

  40. E. I. Chazov,Cardiology [in Russian], Moscow (1985).

  41. N. R. Alpert and M. S. Gordon,Am. J. Physiol.,202, 940–946 (1962).

    PubMed  CAS  Google Scholar 

  42. N. Alpert, B. Hamrell, and L. Mulieri,Ann. Rev. Physiol.,41, 521–537 (1979).

    Article  CAS  Google Scholar 

  43. P. Anversa, G. Olivetti, M. Melissari,et al., J. Mol. Cell Cardiol.,12, 781–795 (1980).

    Article  PubMed  CAS  Google Scholar 

  44. A. Azarcon, D. Applegate, and E. Reisler,J. Biol. Chem.,260, 6047–6053 (1985).

    PubMed  CAS  Google Scholar 

  45. U. Baandrup, R. Florio, M. Rehahn,et al., Br. Heart J.,45, 487–493 (1981).

    PubMed  CAS  Google Scholar 

  46. U. Baandrup, R. A. Florio, F. Roberts, and E. G. J. Olsen,Circulation,63, 1289–1298 (1981).

    PubMed  CAS  Google Scholar 

  47. G. Bachrach, M. Banel, Y. Fishman, and H. Bercovier,Infect. Immun.,65, 267–271 (1997).

    PubMed  CAS  Google Scholar 

  48. R. J. Bing,Fed. Proc.,41, 2443–2446 (1982).

    PubMed  CAS  Google Scholar 

  49. P. A. Brady, A. E. Alekseev, L. A. Aleksandrova,et al., Am. J. Physiol.,271, H2710-H2716 (1996).

    PubMed  CAS  Google Scholar 

  50. B. Brenner and E. Eisenberg,Proc. Natl. Acad. Sci. USA.,83, 3542–3546 (1986).

    Article  PubMed  CAS  Google Scholar 

  51. B. Brenner, M. Schoenberg, J. M. Chalovich,et al., —Ibid. 79, 7288–7291 (1982).

    Article  PubMed  CAS  Google Scholar 

  52. T. P. Burghardt and K. Ajtai, —Ibid.,82, 8478–8482 (1985).

    Article  PubMed  CAS  Google Scholar 

  53. J. Bussemaker, J. H. van Beek, A. B. Groeneveld,et al., J. Mol. Cell Cardiol.,26, 1017–1028 (1994).

    Article  PubMed  CAS  Google Scholar 

  54. J. B. Caulfield and P. E. Wolkowicz,Heart Failure.,6, 138–140 (1990).

    Google Scholar 

  55. K. Clarke and R. Willis,J. Mol. Cell Cardiol.,19, 1153–1160 (1987).

    PubMed  CAS  Google Scholar 

  56. D. A. Cox and M. A. Matlib,Trends Pharmacol. Sci.,14, 408–413 (1993).

    Article  PubMed  CAS  Google Scholar 

  57. A. G. Craig, E. C. Jimenez, J. Dykert,et al., J. Biol. Chem.,272, 4689–4698 (1997).

    Article  PubMed  CAS  Google Scholar 

  58. J. Daizadeh, E. S. Medvedev, and A. A. Stuchrukhov,Proc. Natl. Acad. Sci. USA.,94, 3703–3708 (1997).

    Article  PubMed  CAS  Google Scholar 

  59. M. J. Davies, M. R. Path, I. A. Brooksby,et al., Cather. Cardiovasc. Diagn.,3, 123–130 (1977).

    CAS  Google Scholar 

  60. M. J. Dawson, D. G. Gadian, and D. R. Wilkie,Nature,274, 861–866 (1978).

    Article  PubMed  CAS  Google Scholar 

  61. C. Dufour, E. Dausse, L. Fetler,et al., J. Mol. Cell Cardiol.,26, 1241–1247 (1994).

    Article  PubMed  CAS  Google Scholar 

  62. E. H. Egelman,J. Muscle Res. Cell. Motil.,6, 129–151 (1985).

    Article  PubMed  CAS  Google Scholar 

  63. E. Eisenberg and T. Hill,Science,227, 999–1006 (1985).

    PubMed  CAS  Google Scholar 

  64. E. Q. Eleftheriades, Q. Ming, W. Sharp,et al., Heart Failure,8, 266–274 (1992/1993).

    Google Scholar 

  65. J. M. Fagan, E. F. Wajnberg, L. Culbert, and L. Waxman,Am. J. Physiol.,262, E637-E644 (1992).

    PubMed  CAS  Google Scholar 

  66. L. E. Ford, A. F. Huxley, and R. M. Simmons, —Ibid.,372, 595–609 (1986).

    CAS  Google Scholar 

  67. R. E. Fowles and J. W. Mason,Proc. Cardiovas. Dis.,27, 153–172 (1984).

    Article  CAS  Google Scholar 

  68. D. Gergel and A. I. Cederbaum,Biochemistry,35, 16186–16194 (1996).

    Article  PubMed  CAS  Google Scholar 

  69. C. Gibbs,J. Mol. Cell. Cardiol.,17, 727–731 (1985).

    PubMed  CAS  Google Scholar 

  70. J. Giesen and H. Kammermeier, —Ibid.,12, 891–907 (1980).

    Article  PubMed  CAS  Google Scholar 

  71. T. Guarnieri and E. G. Lakatta,J. Clin. Invest.,85, 1462–1467 (1990).

    PubMed  CAS  Google Scholar 

  72. J. K. Gwathmey, L. Copelas, R. MacKinnon,et al., Circ. Res.,61, 70–76 (1987).

    PubMed  CAS  Google Scholar 

  73. J. Hanson and J. Lowy,J. Mol. Biol.,6, 46–60 (1963).

    Article  CAS  Google Scholar 

  74. C. J. Hardy, R. J. Weiss, P. A. Bottomley, and G. Gerstenblith,Am. Heart J.,122, 795–801 (1991).

    Article  PubMed  CAS  Google Scholar 

  75. D. J. Hearse,Am. J. Cardiol.,44, 1116–1121 (1979).

    Article  Google Scholar 

  76. J. Herzig and J. Ruegg,Myocardial Failure, Eds. G. Reicker,et al., New York (1977), pp. 41–51.

  77. J. W. Herzig,Basic Res. Cardiol.,73, 273–286 (1978).

    Article  PubMed  CAS  Google Scholar 

  78. G. Heusch,Ibid.,86, 197–218 (1991).

    Article  PubMed  CAS  Google Scholar 

  79. S. Highsmith and R. Cooke,J. Muscle Res. Cell Motil.,4, 207–237 (1983).

    Article  CAS  Google Scholar 

  80. D. L. Hillis and E. Braunwald,N. Engl. J. Med.,296, 971–975 (1977).

    Article  PubMed  CAS  Google Scholar 

  81. K. Holmes, D. Popp, W. Gebhard, and W. Kabsch,Nature,347, 44–49 (1990).

    Article  PubMed  CAS  Google Scholar 

  82. A. F. Huxley and R. E. Taylor,J. Physiol.,144, 426–441 (1958).

    PubMed  CAS  Google Scholar 

  83. D. Hwang, A. Damsey, R. Wang,et al., Circulation,96, 4146–4203 (1997).

    PubMed  CAS  Google Scholar 

  84. S. Ishiwata and S. Fujime,J. Mol. Biol.,68, 511–522 (1972).

    Article  PubMed  CAS  Google Scholar 

  85. H. Kammermeier, P. Schmidt, and E. Jungling,J. Mol. Cell Cardiol.,14, 267–277 (1982).

    Article  PubMed  CAS  Google Scholar 

  86. N. V. Karsanov and J. J. Eristavi,Studia Biophys.,85, 29–30 (1981).

    CAS  Google Scholar 

  87. N. V. Karsanov, G. I. Nizharadze, M. P. Pirtskhalaishvili,et al., J. Gen. Physiol. Biophys.,4, 417–423 (1985).

    CAS  Google Scholar 

  88. N. V. Karsanov, M. P. Pirtskhalaishvili, V. I. Semerikova,et al., Basic Res. Cardiol.,81, 199–212 (1986).

    Article  PubMed  CAS  Google Scholar 

  89. N. V. Karsanov, G. V. Sukoyan, D. R. Tatulaschvili,et al., Biomed. Sci.,4, 344–356 (1991).

    Google Scholar 

  90. E. K. Kasper, W. R. Agema, G. M. Hutchins,et al., J. Am. Coll. Cardiol.,23, 586–590 (1994).

    PubMed  CAS  Google Scholar 

  91. A. M. Katz,N. Engl. J. Med.,322, 100–110 (1990).

    Article  PubMed  CAS  Google Scholar 

  92. M. Khananaschvili and N. V. Karsanov,Int. J. Physiol.,4, 307–318 (1987).

    Google Scholar 

  93. R. N. Kitsis and J. Scheuer,Clin. Cardiol.,19, 9–18 (1996).

    PubMed  CAS  Google Scholar 

  94. B. Kunkel, H. Lapp, G. Kober, and M. Kaltenbach,Cardiomyopathy and Myocardial Biopsy. Eds. M. Kaltenbachet al., Berlin, Heidelberg (1978), pp. 271–283.

  95. L. La Vecchia, F. Bedogni, L. Bozzola,et al., Clin. Cardiol.,19, 45–50 (1996).

    PubMed  Google Scholar 

  96. M. G. Levee, M. I. Dabrowska, J. L. Lelli, and D. B. Hinshaw,Am. J. Physiol.,271, C1981-C1992 (1996).

    PubMed  CAS  Google Scholar 

  97. R. Liao, L. Nascimben, J. Friedrich,et al., Circ. Res.,78, 893–902 (1996).

    PubMed  CAS  Google Scholar 

  98. S. Lowey, G. S. Waller, and K. Trybus,Nature,365, 454–456 (1993).

    Article  PubMed  CAS  Google Scholar 

  99. S. Margossian, V. Hatcher, and S. Taylor,Cardiovasc. Res.,27, 216–221 (1993).

    PubMed  CAS  Google Scholar 

  100. J. Marin-Garcia and M. Goldenthal,Ibid.,28, 456–463 (1994).

    PubMed  CAS  Google Scholar 

  101. B. J. Maron, P. Spirito, K. L. Green,et al., J. Am. Coll. Cardiol.,10, 733–742 (1987).

    Article  PubMed  CAS  Google Scholar 

  102. I. Matsubara,Ann. Rev. Biophys. Bioeng.,9, 81–105 (1980).

    Article  CAS  Google Scholar 

  103. I. Matsubara, D. W. Maughan, Y. Saeki, and N. Yagi,J. Physiol.,417, 555–565 (1989).

    PubMed  CAS  Google Scholar 

  104. I. Matsubara, Y. Umazume, and N. YagiContractile mechanisms in muscle. Eds. G. H. Pollack and H. Sugi.-New York (1984), pp. 711–717.

  105. P. M. Matthews, S. R. Williams, A. M. Seymour,et al., Biochem. Biophys. Acta (C),720, 163–171 (1982).

    Article  CAS  Google Scholar 

  106. J.-J. Mercadier, S. Hatem, and K Schwartz,Heart Failure,9, 112–120 (1993).

    Google Scholar 

  107. K. Mihashi, H. Yoshimura, T. Nishio,et al., J. Biochem.,93, 1705–1707 (1983).

    PubMed  CAS  Google Scholar 

  108. H. Miyata, K. Kinosita, and G. Marriott,Ibid.,121, 527–533 (1997).

    PubMed  CAS  Google Scholar 

  109. P. B. Moore, H. E. huxley, and D. DeRosier,J. Mol. Biol.,50, 279–295 (1970).

    Article  PubMed  CAS  Google Scholar 

  110. J.-P. morello and M. Bouvier,Biochem. Cell Biol.,74, 449–457 (1996).

    Article  PubMed  CAS  Google Scholar 

  111. M. A. Movssesian, M. Bristow, and J. Krall,Circ. Res.,65, 1141–1144 (1989).

    Google Scholar 

  112. V. Muller, G. Basset, D. R. Nelson, and M. Klingenberg,Biochemistry,35, 16132–16143 (1996).

    Article  PubMed  CAS  Google Scholar 

  113. K. Nakamura, H. Kusuoka, G. Ambrosio, and L. Becker,Am. J. Physiol.,264, H670-H678 (1993).

    PubMed  CAS  Google Scholar 

  114. S. Neubauer, M. Horn, A. Laser, and M. Goodde,Eur. Heart J.,16, Suppl. 1, 8 (1995).

    Google Scholar 

  115. F. Oosawa,Actin Structure and Function in Muscle and Non-Muscle Cells, Eds. C. Dos Remedios and J. Barden, Sydney (1983), pp. 69–79.

  116. L. H. Opie,Cardiovas. Res.,26, 721–733; 817–830 (1992).

    Article  CAS  Google Scholar 

  117. T. Ozawa,Herz,19, 105–118 (1994).

    PubMed  CAS  Google Scholar 

  118. J. Schaper and S. Hein,Heart Failure,9, 95–111 (1993).

    Google Scholar 

  119. J. Schaper, E. Meiser, and G. Stammler,Circ. Res.,56, 377–391 (1985).

    PubMed  CAS  Google Scholar 

  120. A. Schapira, J. Cooper, and J. Morgan-Hughes,et al., Lancet, No. 8584, 500–503 (1988).

    Article  Google Scholar 

  121. M. Schigekawa, J. P. Dougherty, and A. M. Katz,J. Biol. Chem.,253, 1442–1350 (1978).

    Google Scholar 

  122. G. Schwartz, S. Schaefer, D. Meyerhoff,et al., Circ. Res.,67, 490–500 (1990).

    PubMed  CAS  Google Scholar 

  123. J. Sievers, W. W. Parmley, T. James, and J. Wikman-Coffelt,Ibid.,53, 759–766 (1983).

    PubMed  CAS  Google Scholar 

  124. F. M. Siri, J. Krueger, C. Nordin,et al., Am. J. Physiol.,261, H514-H530 (1991).

    PubMed  CAS  Google Scholar 

  125. J. Smith, W. Barry, J. Marsch,et al., Am. Heart J.,103, 716–723 (1982).

    Article  PubMed  CAS  Google Scholar 

  126. R. J. Solaro,Circulation.,85, 1945–1946 (1992).

    PubMed  CAS  Google Scholar 

  127. N. Sperilakis,Heart Failure,6, 212–220 (1990/1991).

    Google Scholar 

  128. B. Swynghedauw, K. Schwartz, C. Apstein,Am. J. Cardiol.,54, 437–440 (1984).

    Article  PubMed  CAS  Google Scholar 

  129. D. D. Thomas,Biophys. J.,24, 439–462 (1978).

    Article  PubMed  CAS  Google Scholar 

  130. H. P. Vosberg,Herz,19, 75–83 (1994).

    PubMed  CAS  Google Scholar 

  131. A. J. Warring and R. Cooke,Arch. Biochem. Biophys.,252, 197–205 (1987).

    Article  Google Scholar 

  132. H. Weiss, J. Neubauer, J. Lipp, and A. Sinha,Circ. Res.,42, 394–401 (1978).

    PubMed  CAS  Google Scholar 

  133. R. White and B. Wittenberg,Biophys. J.,65, 196–204 (1993).

    PubMed  CAS  Google Scholar 

  134. N. Yonezawa, E. Nishida, K. Iida,et al., J. Biol. Chem.,265, 8382–8386 (1990).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Republican Research Center of Medical Biophysics, Ministry of Health of Georgia Republic, Tbilisi

    N. V. Karsanov

Authors
  1. N. V. Karsanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 124–140, August, 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karsanov, N.V. Energy, structure, conformation, and heart failure. Bull Exp Biol Med 128, 765–778 (1999). https://doi.org/10.1007/BF02433812

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02433812

Key Words

Search

Navigation