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Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Nine weeks of compulsory morphine drinking decreased the specific binding of3H-muscimol to GABA receptors and14C-NAD to rat brain synaptic membranes and increased the synaptosomal uptake of14C-GABA. These effects of morphine on the GABA-benzodiazepine receptor complex were reversed by excessive doses of vitamin B3.

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References

  1. T. A. Voronina,Farmakol. Toksikol.,44, No. 6, 680–683 (1981).

    PubMed  CAS  Google Scholar 

  2. A. I. Fomenko, G. V. Donchenko, A. A. Khalmuradov, and S. P. Stepanenko,Ukr. Biokhim. Zh.,69, No. 2, 46–50 (1997).

    PubMed  CAS  Google Scholar 

  3. A. I. Fomenko, P. K. Parkhomets, G. V. Donchenko, and S. P. Stepanenko,Vopr. Med. Khimii,39, No. 4, 48–50 (1993).

    PubMed  CAS  Google Scholar 

  4. A. I. Fomenko, G. V. Chichkovskaya, P. K. Parkhomets, and G. V. Donchenko,Ukr. Biochim. Zh.,64, No. 6, 109–113 (1992).

    CAS  Google Scholar 

  5. J. Abita, R. Chicheportiche, H. Shvetz, and M. Lozdunski,Biochemistry,16, No. 9, 1838–1864 (1977).

    Article  PubMed  CAS  Google Scholar 

  6. R. M. Burton, N. O. Kaplan, A. Goldin,Science,127, No. 3288, 30–31 (1958).

    PubMed  CAS  Google Scholar 

  7. Y. Ito and K. Kuriama,Brain Res.,236, No. 2, 351–363 (1982).

    Article  PubMed  CAS  Google Scholar 

  8. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. I. Randall,J. Biol. Chem.,193, No. 1, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  9. K. Manfred,Neurochem. Int.,5, No. 6, 673–674 (1983).

    Article  Google Scholar 

  10. H. Mochler and T. Okada,Science,198, No. 4320, 849–851 (1977).

    Google Scholar 

  11. D. W. Woolley, ——Ibid.,128, No. 33-34, 1277–1278 (1958).

    PubMed  CAS  Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 295–301, March, 1999

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Fomenko, A.I., Donchenko, G.V. & Stepanenko, S.P. Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes. Bull Exp Biol Med 127, 266–268 (1999). https://doi.org/10.1007/BF02433352

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  • DOI: https://doi.org/10.1007/BF02433352

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