Bulletin of Experimental Biology and Medicine

, Volume 127, Issue 3, pp 266–268 | Cite as

Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes

  • A. I. Fomenko
  • G. V. Donchenko
  • S. P. Stepanenko
Biophysics and Biochemistry
  • 25 Downloads

Abstract

Nine weeks of compulsory morphine drinking decreased the specific binding of3H-muscimol to GABA receptors and14C-NAD to rat brain synaptic membranes and increased the synaptosomal uptake of14C-GABA. These effects of morphine on the GABA-benzodiazepine receptor complex were reversed by excessive doses of vitamin B3.

Key Words

vitamin B3 NAD morphine GABA-benzodiazepine receptor complex 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • A. I. Fomenko
    • 1
  • G. V. Donchenko
    • 1
  • S. P. Stepanenko
    • 1
  1. 1.A. V. Palladin Institute of BiochemistryUkrainian Academy of SciencesKievUkraine

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