Abstract
Nine weeks of compulsory morphine drinking decreased the specific binding of3H-muscimol to GABA receptors and14C-NAD to rat brain synaptic membranes and increased the synaptosomal uptake of14C-GABA. These effects of morphine on the GABA-benzodiazepine receptor complex were reversed by excessive doses of vitamin B3.
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T. A. Voronina,Farmakol. Toksikol.,44, No. 6, 680–683 (1981).
A. I. Fomenko, G. V. Donchenko, A. A. Khalmuradov, and S. P. Stepanenko,Ukr. Biokhim. Zh.,69, No. 2, 46–50 (1997).
A. I. Fomenko, P. K. Parkhomets, G. V. Donchenko, and S. P. Stepanenko,Vopr. Med. Khimii,39, No. 4, 48–50 (1993).
A. I. Fomenko, G. V. Chichkovskaya, P. K. Parkhomets, and G. V. Donchenko,Ukr. Biochim. Zh.,64, No. 6, 109–113 (1992).
J. Abita, R. Chicheportiche, H. Shvetz, and M. Lozdunski,Biochemistry,16, No. 9, 1838–1864 (1977).
R. M. Burton, N. O. Kaplan, A. Goldin,Science,127, No. 3288, 30–31 (1958).
Y. Ito and K. Kuriama,Brain Res.,236, No. 2, 351–363 (1982).
O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. I. Randall,J. Biol. Chem.,193, No. 1, 265–275 (1951).
K. Manfred,Neurochem. Int.,5, No. 6, 673–674 (1983).
H. Mochler and T. Okada,Science,198, No. 4320, 849–851 (1977).
D. W. Woolley, ——Ibid.,128, No. 33-34, 1277–1278 (1958).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 295–301, March, 1999
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Fomenko, A.I., Donchenko, G.V. & Stepanenko, S.P. Effects of chronic morphine intake on binding of NAD and GABA-benzodiazepine agonists to synaptic membranes. Bull Exp Biol Med 127, 266–268 (1999). https://doi.org/10.1007/BF02433352
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DOI: https://doi.org/10.1007/BF02433352