Abstract
The adenosine deaminase locus (Ada) in the mouse has been localized byin situ hybridization to band 2H3. Linkage analysis of backcross data has shown thatAda is 13.8±2.7 cM from the coat texture mutant, ragged,Ra. From the results of earlier work (Abbott, C. M.,et al., Proc. Natl. Acad. Sci. USA 83:693, 1986), it had been suggested thatwst was a low-activity allele ofAda, but this cannot be so becauseAda andwst have been found to be nonallelic.
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Abbott, C. M., Skidmore, C. J., Searle, A. G., and Peters, J. (1986). Deficiency of adenosine deaminase in the wasted mouse.Proc. Natl. Acad. Sci. USA 83693.
Beechey, C. V., and Evans, E. P. (1978). Personal communication.Mouse News Lett. 5846.
Davisson, M. T., Roderick, T. H., and Doolittle, D. P. (1989). Recombination percentages and chromosomal assignments. In Lyon, M. F., and Searle, A. G. (eds.),Genetic Variants and Strains of the Laboratory Mouse 2nd ed., Oxford University Press, Oxford, p. 432.
Evans, E. P. (1987). Karyotyping and sexing of gametes, embryos and fetuses andin situ hybridization to chromosomes. In Monk, M. (ed.),Mammalian Development: A Practical Approach IRL Press Oxford, Washington, D.C., p. 93.
Geiger, J. D., and Nagy, J. I. (1986). Lack of adenosine deaminase in the mutant mousewasted.FEBS Lett. 208431.
Lyon, M. F., Zenthon, J., Evans, E. P., Burtenshaw, M. D., Wareham, K. A., and Williams, E. D. (1986). Lack of inactivation of an X linked gene physically separated from the inactivation centre.J. Exp. Embryol. Morphol. 9775.
Nash, H. R. (1984). Personal communication.Mouse News Lett. 7133.
Nesbitt, M. N., and Francke, U. (1973). A system of nomenclature of band patterns of mouse chromosomes.Chromosoma (Berl.)41145.
Siciliano, M. J., Fournier, R. E. K., and Stallings, R. L. (1984). Regional assignment ofADA andITPA to mouse chromosome 2 (C1-ter).J. Hered 75175.
Siracusa, L. D., Buchberg, A. M., Copeland, N. G., and Jenkins, N. A. (1989). Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murineagouti coat color locus.Genetics 122669.
Siracusa, L. D., Silan, C. M., Justice, M. J., Mercer, J. A., Bauskin, A. R., Ben-Neriah, Y., Duboule, D., Hastie, N. D., Copeland, N. G., and Jenkins, N. A. (1990). A molecular genetic linkage map of mouse chromosome 2.Genomics 6491.
Sweet, H. O. (1984). Personal communication.Mouse News Lett. 7131.
Willis, E. H., Carson, D. A., and Shultz, L. D. (1987). Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.Biochem. Biophys. Res. Comm. 145581.
Yeung, C.-Y., Ingolia, D. E., Roth, D. B., Shoemaker, C., Al-Ubaidi, M. R., Yen, J.-Y., Ching, C., Bobonis, C., Kaufman, R. J., and Kellems, R. E. (1985). Identification of functional adenosine deaminase cDNA clones by complementation inE. coli.J. Biol. Chem 26010299.
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Abbott, C.M., Evans, E.P., Burtenshaw, M. et al. Adenosine deaminase,Ada, is in mouse chromosome 2H3, and is not allelic with wasted,wst . Biochem Genet 29, 537–544 (1991). https://doi.org/10.1007/BF02426869
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DOI: https://doi.org/10.1007/BF02426869