Abstract
Each of 8 subjects was exposed to a concentration of approx. 40 ppm trichloroethylene for 4 h and each of 4 subjects to a concentration of approx. 50 ppm for 4 h/day on 5 successive days. The concentrations of trichloroethylene and the metabolites trichloroethanol and trichloroacetic acid were determined in the blood, urine and the expired breath. Repeated exposures were followed by a slight increase of trichloroethylene and trichloroethanol in the blood. After a short time, the urinary excretion of trichloroethanol reached a maximal level and then remained constant. During the exposure the trichloroacetic acid-concentration increased continuously from one day to the other.
Zusammenfassung
8 Personen wurden einmal 4 Std lang einer Trichloroäthylenkonzentration von ca. 40 ppm und weitere 4 Personen täglich 4 Std lang einer Konzentration von ca. 50 ppm an 5 aufeinanderfolgenden Tagen exponiert.
In Atemluft, Blut und Harn wurden die Konzentrationen von Trichloräthylen und den Metaboliten Trichloräthanol und Trichloressigsäure bestimmt
Als Folge der wiederholten Exposition zeichnete sich die Tendenz zu einem leichten Anstieg des Trichloräthylen- und Trichloräthanolspiegels im Blut ab.
Die Trichloräthanolkonzentration im Harn erreichte nach kurzer Zeit ein konstant bleibendes Niveau. Die Trichloressigsäureausscheidung nahm kontinuierlich von Tag zu Tag zu.
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Kimmerle, G., Eben, A. Metabolism, excretion and toxicology of trichloroethylene after Inhalation. Arch Toxicol 30, 127–138 (1973). https://doi.org/10.1007/BF02425930
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DOI: https://doi.org/10.1007/BF02425930