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Analysis of a new class I gene mapping to theHmt region of the mouse

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Abstract

The major histocompatibility complex (MHC) of the BALB/c mouse contains three genes encoding classical class I molecules, as well as at least 32 nonclassical class I genes. Although much is known about the genes encoding the classical class I molecules, the majority of the nonclassical genes have not been characterized. This report describes a newly identified nonclassical class I gene,Thy19.4, which contains an open reading frame and resembles in several regards the genes encoding classical class I molecules. The similarities include shared amino acid sequence motifs which suggest that the putative Thy19.4 molecule may assume a tertiary structure similar to that of the classical class I molecules, as well as widespread transcription in a variety of tissues. However, unlike the classical class I genes, theThy19.4 gene maps approximately 1 cm distal to theTla region of the MHC, in the same region as the gene encoding theHmt element of the maternally transmitted antigen.

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Author notes

  1. Stephen W. Hunt III

    Present address: Department of Medicine, University of North Carolina, 27599, Chapel Hill, NC, USA

  2. Hilde Cheroutre

    Present address: Department of Microbiology and Immunology, University of California, 90024, Los Angeles, CA, USA

  3. Sue Richards

    Present address: Gene Screen Corp., Dallas, TX 75207, USA

Authors and Affiliations

  1. Division of Biology, 147-75, California Institute of Technology, 91125, Pasadena, CA, USA

    Kurt A. Brorson, Stephen W. Hunt III, Hilde Cheroutre & Leroy Hood

  2. Howard Hughes Medical Institute and Departments of Microbiology and Biochemistry, University of Texas Southwestern Medical Center, 75235-9050, Dallas, TX, USA

    Sue Richards & Kirsten Fischer Lindahl

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  1. Kurt A. Brorson
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  2. Sue Richards
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Additional information

The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the association number M26156.

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Brorson, K.A., Richards, S., Hunt, S.W. et al. Analysis of a new class I gene mapping to theHmt region of the mouse. Immunogenetics 30, 273–283 (1989). https://doi.org/10.1007/BF02421331

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