Abstract
Various methods of determining cyclosporin (CyA) levels in patients after kidney transplantation were compared. These included polyclonal antibody (pcAb-), specific and nonspecific monoclonal antibody (S- and NmcAb-) radioimmunoassays (RIA), and high performance liquid chromatography (HPLC). The results obtained by the various methods when compared showed some correlation but did not correspond. A probable explanation for part of this noncorrespondence is the presence of monoclonally crossreactive metabolites (CyA-M). Another reason was that the concentration of CyA in the standards supplied with the RIA kits was found to be higher than stated.
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Randleff-Rasmussen, G.M., Oosthuizen, M.M.J. & Myburgh, J.A. An explanation of the noncorrespondence between assessment methods of cyclosporin. Transplant Int 2, 181–186 (1989). https://doi.org/10.1007/BF02414531
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DOI: https://doi.org/10.1007/BF02414531