Summary
Intestinal calcium-binding protein (CaBP) levels of rats fed a high (1.5%) Ca diet were the same whether the animals were parathyroidectomized (PTX), sham-operated controls pair-fed with the PTX animals, or sham-operated controls fed ad libitum. Consequently, a given base level of CaBP seems to be parathyroid hormone independent and not closely related to feed intake. On the other hand, whereas the ad libitum fed controls more than doubled their intestinal CaBP in response to a 2-day low-calcium (0.02%) regimen, neither the parathyroidectomized animals nor the pair-fed sham-operated controls were able to do so. Since the latter two groups consumed less feed and therefore less vitamin D than the ad libitum fed animals, the inability to increase CaBP in response to a low-calcium diet may have been caused by a restricted vitamin D intake rather than by the absence of parathyroid hormone.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Haussler, M.: Vitamin D: Mode of action and biomedical applications, Nutr. Rev.32:257–266, 1974
Fraser, D.E., Kodicek, E.: Unique biosynthesis by kidney of a biologically active vitamin D metabolite, Nature228:764–766, 1970
Lawson, D.E.M., Fraser, D.E., Kodicek, E., Morris, H.R., Williams, D.H.: Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism, Nature230:228–230, 1971
DeLuca, H.F., Schnoes, H.K.: Metabolism and mechanism of action of vitamin D, Annu. Rev. Biochem.45:631–640, 1976
Battacharyya, M., DeLuca, H.F.: The regulation of rat liver calciferol 25-hydroxylase, J. Biol. Chem.248:2969–2973, 1973
DeLuca, H.F.: Metabolism of vitamin D: current status, Am. J. Clin. Nutr.29:1258–1270, 1976
Edelstein, S., Harell, A., Bar, A., Hurwitz, S.: The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets, Biochim. Biophys. Acta385:438–442, 1975
Edelstein, S., Noff, D., Sinai, L., Harell, A., Puschett, J., Golub, E.E., Bronner, F.: Vitamin D metabolism and expression in rats fed on low-calcium and low-phosphorus diets, Biochem. J.170:227–233, 1978
Freund, T.S., Bronner, F.: Regulation of intestinal calciumbinding protein by calcium intake in the rat, Am. J. Physiol.228:861–869, 1975
Garabedian, M., Holick, M., DeLuca, H.F., Boyle, I.T.: Control of 25-hydroxycholecalciferol metabolism by parathyroid glands, Proc. Natl. Acad. Sci. U.S.A.69:1673–1676, 1972
Fraser, D.R., Kodicek, E.: Regulation of 25-hydroxycholecalciferol 1-hydroxylase activity in kidney by parathyroid hormone, Nature [New Biol.]241:163–166, 1973
Golub, E.E., Reid, M., Bossak, C., Wolpert, L., Bronner, F.: The effect of calcium on calcium-binding protein induction in vitro, Fed. Proc.36:456, 1977
Bruns, M.E.H., Fliesher, E.B., Avioli, L.V.: Control of vitamin D-dependent calcium-binding protein in rat intestine by growth and fasting, J. Biol. Chem.252:4145–4150, 1977
Bar, A., Hurwitz, S., Edelstein, S.: Response of renal calcium-binding protein. Independence of kidney vitamin D hydroxylation, Biochim. Biophys. Acta411:106–112, 1975
Bronner, F., Freund, T.S.: Intestinal CaBP: a new quantitative index of vitamin D deficiency in the rat, Am. J. Physiol.229:689–694, 1975
Brumbaugh, P.F., Haussler, D.H., Bressler, R., Haussler, M.R.: Radioreceptor assay for 1α,25-dihyroxyvitamin D3, Science183:1089–1091, 1974
Hughes, M.R., Braumbaugh, P.F., Haussler, M.R., Wergedal, J.E., Baylink, D.J.: Regulation of 1α,25-dihydroxy vitamin D3 by calcium and phosphate in the rat, Science190:578–580, 1975
Grubenmann, W., Binswanger, U., Hunziker, W., Fischer, J.A.: Effects of calcium intake on renal function and plasma immunoreactive parathyroid hormone levels in rats, Horm. Metab. Res.10:438–443, 1978
Trechsel, U., Eisman, J.A., Bonjour, J.-P., Fleisch, H.: Evidence for a calcium-dependent, PTH-independent regulation of plasma 1,25-dihydroxy vitamin D in rats. In A. Norman et al. (eds.): Fourth Workshop on Vitamin D. De Gruyter, Berlin (to be published)
Kalk, W., Pimstone, D.: Calcium-binding protein and vitamin D metabolism in experimental protein malnutrition, Br. J. Nutr.32:569–578, 1974
Thomasset, M., Cuisinier-Gleizes, P., Mathieu, H.: Differences in duodenal calcium-binding protein (CaBP) in response to a low-calcium or a low-phosphorus intake, Calcif. Tissue Res. [Suppl.]21:39–41, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thomasset, M., Cuisinier-Gleizes, P., Mathieu, H. et al. Regulation of intestinal calcium-binding protein in rats: Role of parathyroid hormone. Calcif Tissue Int 29, 141–145 (1979). https://doi.org/10.1007/BF02408069
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02408069