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Bone mineralization and metabolism of3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract

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Summary

Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid maturation. Significant decreases in osteoid width and mineralizing front width, as well as a 60% increase in the rate of initial mineralization were observed in the PTE-treated group. Conversion of3H-25-hydroxyvitamin D3 to3H-1,25-dihydroxyvitamin D3 was 4-fold higher in the PTE-treated group than in the untreated animals. Increased formation of 1,25-dihydroxyvitamin D3 in response to treatment with PTE may play a major role in correcting the mineralizing defect resulting from thyroparathyroidectomy.

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Authors and Affiliations

  1. Department of Medicine, University of Washington School of Medicine, Seattle, Washington

    J. I. Rader, G. A. Howard, E. Feist, R. T. Turner & D. J. Baylink

  2. Veterans Administration Medical Center, American Lake, 98493, Tacoma, Washington, USA

    J. I. Rader, G. A. Howard, E. Feist, R. T. Turner & D. J. Baylink

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  1. J. I. Rader
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  2. G. A. Howard
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  3. E. Feist
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  4. R. T. Turner
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  5. D. J. Baylink
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Rader, J.I., Howard, G.A., Feist, E. et al. Bone mineralization and metabolism of3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract. Calcif Tissue Int 29, 21–26 (1979). https://doi.org/10.1007/BF02408051

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  • DOI: https://doi.org/10.1007/BF02408051

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