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Mineralization Impairment Due to Vitamin D Deficiency in Bone Histomorphometry

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Osteoporotic Fracture and Systemic Skeletal Disorders

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Abstract

Vitamin D has an essential nutritional role for the regulation of bone metabolism in the skeleton. Serum 25-hydroxyvitaminD (25OHD), as an indicator of vitamin D status, is reportedly beneficial for human bone physiological functions. Clinically, vitamin D deficiency initially induces secondary hyperparathyroidism and impaired bone mineralization. The defects of mineralization result in bone softening, clinically known as osteomalacia. In the histomorphometric quantitative evaluation, disturbance of bone mineralization was diagnosed based on criteria from different stages.

The present invited review was completed and submitted to the publisher on 04-Apr-21. 

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Authors and Affiliations

  1. Niigata Bone Science Institute, Niigata, Japan

    Noriaki Yamamoto, Taketoshi Shimakura & Hideaki E. Takahashi

  2. Department of Orthopedic Surgery, Niigata Rehabilitation Hospital, Niigata, Japan

    Noriaki Yamamoto, Taketoshi Shimakura & Hideaki E. Takahashi

  3. Department of Orthopedic Surgery, Nishiniigata Central Hospital, Niigata, Japan

    Yoshinori Takahashi

Authors
  1. Noriaki Yamamoto
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  2. Yoshinori Takahashi
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  3. Taketoshi Shimakura
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  4. Hideaki E. Takahashi
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Corresponding author

Correspondence to Noriaki Yamamoto .

Editor information

Editors and Affiliations

  1. Niigata Bone Science Institute, Niigata Rehabilitation Hospital, Niigata, Japan

    Hideaki E. Takahashi

  2. Department of Anatomy, Cell Biology and Physiology, Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA

    David B. Burr

  3. Niigata Bone Science Institute, Niigata Rehabilitation Hospital, Niigata, Japan

    Noriaki Yamamoto

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Yamamoto, N., Takahashi, Y., Shimakura, T., Takahashi, H.E. (2022). Mineralization Impairment Due to Vitamin D Deficiency in Bone Histomorphometry. In: Takahashi, H.E., Burr, D.B., Yamamoto, N. (eds) Osteoporotic Fracture and Systemic Skeletal Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-16-5613-2_17

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  • DOI: https://doi.org/10.1007/978-981-16-5613-2_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-5612-5

  • Online ISBN: 978-981-16-5613-2

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