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Mössbauer spectroscopy, electron microscopy and electron diffraction studies of small particle magnetic systems: Identification of disease specific haemosiderins

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Abstract

Mössbauer spectroscopy has shown that the iron-containing cores of the biological iron storage material haemosiderin produced under normal and various pathological conditions are significantly different in their magnetic properties. The differences have been correlated with information on the particle size, morphology, crystallinity and mineral form of the haemosiderin cores obtained by complementary electron microscopy and electron diffraction studies. These results have important implications for the use of Mössbauer spectroscopy in determining the properties of small particle magnetic systems and also considerable relevance for the improved understanding and treatment of iron overload disease.

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Authors and Affiliations

  1. Department of Physics, University of Liverpool, L69 3BX, Liverpool, UK

    D. P. E. Dickson, N. M. K. Reid & R. J. Ward

  2. School of Chemistry, University of Bath, BA2 7AY, Bath, UK

    S. Mann & V. J. Wade

  3. Division of Clinical Cell Biology, MRC Clinical Research Centre, HA1 3UJ, Harrow, UK

    T. J. Peters

Authors
  1. D. P. E. Dickson
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  2. N. M. K. Reid
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  3. S. Mann
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  4. V. J. Wade
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  5. R. J. Ward
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  6. T. J. Peters
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Dickson, D.P.E., Reid, N.M.K., Mann, S. et al. Mössbauer spectroscopy, electron microscopy and electron diffraction studies of small particle magnetic systems: Identification of disease specific haemosiderins. Hyperfine Interact 45, 223–231 (1989). https://doi.org/10.1007/BF02405882

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