Skip to main content
Log in

Risk analysis for worker exposure to benzene

  • Environmental Auditing
  • Published:
Environmental Management Aims and scope Submit manuscript

Abstract

Cancer risk factors (characterized by route, dose, dose rate per kilogram, fraction of lifetime exposed, species, and sex) were derived for workers exposed to benzene via inhalation or ingestion. Exposure at the current Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) and at leaking underground storage tank (LUST) sites were evaluated. At the current PEL of 1 ppm, the theoretical lifetime excess risk of cancer from benzene inhalation is ten per 1000. The theoretical lifetime excess risk for worker inhalation exposure at LUST sites ranged from 10 to 40 per 1000. These results indicate that personal protection should be required. The theoretical lifetime excess risk due to soil ingestion is five to seven orders of magnitude less than the inhalation risks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature Cited

  • ATSDR (Agency for Toxic Substances and Disease Registry). 1989. Toxicological profile for benzene. PB89-209464, pp. 16, 37, 110.

  • Aksoy, M., E. Erdem, and G. Din Col. 1974. Leukemia in shoe-workers exposed chronically to benzene.Blood 44:837–841.

    CAS  Google Scholar 

  • Brown, H. S. 1986. A critical review of current approaches to determining how clean is clean at hazardous waste sites.Hazardous Waste and Hazardous Materials 3:233–260.

    CAS  Google Scholar 

  • Cronkite, E. P. 1986. Benzene: Hematotoxicity and leukemogenesis.Blood Cells 12:129–137.

    CAS  Google Scholar 

  • Cronkite, E. P., R. T. Drew, T. Inoue, and J. E. Bullis. 1985. Benzene hematotoxicity and leukemogenesis.American Journal of Industrial Medicine 7:447–456.

    CAS  Google Scholar 

  • Cronkite, E. P., R. T. Drew, T. Inoue, Y. Hirabayashi, and J. E. Bullis. 1989. Hematotoxicity and carcinogenicity of inhaled benzene.Environmental Health Perspectives 82:97–108.

    CAS  Google Scholar 

  • Decoufle, P., W. A. Blattner, and A. Blair. 1983. Mortality among chemical workers exposed to benzene and other agents.Environmental Research 30:16–25.

    Article  CAS  Google Scholar 

  • EPA. 1990. Health effects assessment summary tables. PB90-921103, p. B-2.

  • Fishbein, L. 1984. An overview of environmental and toxicological aspects of aromatic hydrocarbons. Elsevier, New York, p. 201.

    Google Scholar 

  • Hallenbeck, W. H., and K. M. Cunningham. 1986. Quantitative risk assessment for environmental and occupational health. Lewis Publishers, Inc. Chelsea, Michigan, pp. 43–72.

    Google Scholar 

  • Kramer, W. A. 1989. Benzene exposure assessment of underground storage tank contractors.Applied Industrial Hygiene 4:269–271.

    CAS  Google Scholar 

  • Maltoni, C., G. Conti, G. Cotti, and F. Belpoggi. 1985. Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncology.American Journal of Industrial Medicine 4:589–630.

    Google Scholar 

  • Maltoni, C., A. Ciliberti, G. Cotti, B. Conti, and F. Belpoggi. 1989. Benzene, an experimental multipotential carcinogen: Results of the long-term bioassays performed at the Bologna Institute of Oncology.Environmental Health Perspectives 82:109–124.

    CAS  Google Scholar 

  • NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of benzene in F344/N Rats and B6C3F1 Mice. NTP TR 289.

  • Ott, M. G., J. C. Townsend, W. A. Fishbeck, and R. A. Langner. 1978. Mortality among individuals occupationally exposed to benzene.Archives of Environmental Health 1:3–10.

    Google Scholar 

  • Rinsky, R. A., A. B. Smith, R. Hornung, T. G. Filloon, R. J. Young, A. H. Olun, and P. J. Landrigan. 1987. Benzene and leukemia: An epidemiologic risk assessment.New England Journal of Medicine 316:1044–1050.

    Article  CAS  Google Scholar 

  • Shamsky, S., and B. Samimi. 1987. Organic vapors at underground gasoline tank removal sites.Applied Industrial Hygiene 2:242–245.

    CAS  Google Scholar 

  • Snyder, C. A., B. D. Goldstein, A. R. Sellakumar, I. Bromberg, S. Laskin, and R. E. Albert. 1980. Inhalation toxicology of benzene: Incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57B1/6J mice.Toxicology and Applied Pharmacology 54:323–331.

    Article  CAS  Google Scholar 

  • Snyder, C. A., A. R. Sellakumar, D. J. James, and R. E. Albert. 1988. The carcinogenicity of discontinuous inhaled benzene exposures in CD-1 and C57B1/6 mice.Archives of Toxicology 62:331–335.

    Article  CAS  Google Scholar 

  • Tsai, S. P., C. P. Wen, N. S. Weiss, O. Wong, W. A. McClellan, and R. L. Gibson. 1983. Retrospective mortality and medical surveillance studies of workers in benzene areas of refineries.Journal of Occupational Medicine 25:685–692.

    CAS  Google Scholar 

  • Wong, O. 1987. An industry wide mortality study of chemical workers occupationally exposed to benzene.British Journal of Industrial Medicine 44:365–395.

    CAS  Google Scholar 

  • Yin, S. N., G. L. Li, F. D. Tain, S. I. Fu, C. Jin, Y. J. Chen, S. J. Luo, P. Z. Ye, J. Z. Shang, G. C. Wang, X. C. Shang, H. N. Wu, and Q. C. Zhong. 1987. Leukemia in benzene workers: A retrospective cohort study. British Journal of Industrial Medicine 44:124–128.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hallenbeck, W.H., Flowers, R.E. Risk analysis for worker exposure to benzene. Environmental Management 16, 415–420 (1992). https://doi.org/10.1007/BF02400081

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02400081

Key words

Navigation