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HPLC analysis of radiolabeled octreotide

  • Radiochemical Methods and Production of Radionuclides
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Abstract

Radiolabeled somatostatin analogue is a useful ligand for scintigraphic imaging of somatostatin receptor-bearing tumors. In this study, we investigated the effects of different radiolabeling conditions on labeling yield and ratio between mono-iodinated and di-iodinated125I-Tyr3-octreotide by HPLC analysis. In vitro and in vivo stabilities of125I-Tyr3-octreotide and111In-DTPA-D-Phe1-octreotide were also determined. Both radiolabeled compounds were relatively stable in vitro, but were decomposed to free125I− and111In-DTPA in vivo, respectively.

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Authors and Affiliations

  1. China Institute of Atomic Energy, P. O. Box 275(58), 102413, Beijing, P. R. China

    F. Wang, H. Q. Fan, D. M. Chen, H. S. Bai, Z. Chen &  L. Xiao

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  1. F. Wang
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  2. H. Q. Fan
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  3. D. M. Chen
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  4. H. S. Bai
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  5. Z. Chen
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  6. L. Xiao
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Correspondence to L. Xiao.

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Wang, F., Fan, H.Q., Chen, D.M. et al. HPLC analysis of radiolabeled octreotide. J Radioanal Nucl Chem 236, 205–207 (1998). https://doi.org/10.1007/BF02386343

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  • DOI: https://doi.org/10.1007/BF02386343

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