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Effect of peroral AA-calcium on whole blood ionized calcium levels in patients with hypoparathyroidism. A dose-finding pilot study

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Abstract

AA-Calcium tablets are reported by the Fujita group (1990) to have a good bioavailability. Calcium supplementation is an important part of the substitution procedure of patients with parathyroid hormone deficiency.

Our technique implies a fast method for analysis of whole-blood ionized calcium (B-Ca++) in small amounts of blood. This technique seems to be well suited for comparing the bioavailability of different calcium compounds, expressed as the increase in whole-blood ionized calcium.

The final goal of the study is to compare the effect on B-Ca++ of calcium supplemented in tablet-form as oyster shell electrolysate (AA-Calcium) or calcium carbonate randomly and blindly administered to patients with hypoparathyroidism.

A dose-finding study has been made by means of giving AA-Calcium tablets to ten hypoparathyroid patients with reduced dose of vitamin D, to find the calcium-dose needed to achieve a normal B-Ca++ level between 1.15 and 1.20 mmol/l.

The result of the dose-finding part of the study seems to be in favour of giving 1 gram of AA-Calcium in the morning.

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Authors and Affiliations

  1. Dept. of Endocrinology, Karolimska Inst. and Hospital, 10401, Stockholm, Sweden

    HE Sjöberg M.D., Ph.D. & Maria Sääf

  2. Dept. of Nutrition, School of Public Health, University of North Carolina, USA

    John JB. Anderson

Authors
  1. HE Sjöberg M.D., Ph.D.
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  2. Maria Sääf
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  3. John JB. Anderson
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Sjöberg, H., Sääf, M. & Anderson, J.J. Effect of peroral AA-calcium on whole blood ionized calcium levels in patients with hypoparathyroidism. A dose-finding pilot study. J Bone Miner Metab 11, S17–S21 (1993). https://doi.org/10.1007/BF02383537

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  • DOI: https://doi.org/10.1007/BF02383537

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