Pharmaceutical and medical applications of polymer electrolytes

Abstract

Classic methods of drug delivery have embraced a number of routes into the site of pharmacological action. Modern preference, wherever possible, is for a non-invasive route to minimise the chance of cross infection, especially of the AIDS virus. The skin, which is the largest organ in the human body, is a particularly appealing route as, in the absence of wounds and blemishes, it offers a natural, high-integrity, barrier to the outside world. Skin patches containing active drug that is allowed to diffuse passively across the external skin barrier into the bloodstream now enjoy wide application but a problem is that the rate of egress is often slow.

For certain ionic drugs, including local anaesthetics and, more recently, peptides and gene-based, biotechnological engineered pharmaceuticals, it is possible substantially to enhance transdermal transport by iontophoresis. The technique of iontophoresis facilitates the passage of ionic drugs through the skin using an electric current. Ionically conducting polymers (polymer electrolytes) are potential candidates as hosts for drugs to be delivered iontophoretically.

Key issues affecting iontophoretic delivery are reviewed in this paper and the potential role of polymer electrolyte materials in iontophoretic devices will be described.