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Iontophoretic Transport Mechanisms and Factors Affecting Electrically Assisted Delivery

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

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Abstract

Transdermal iontophoresis enables hydrophilic, charged, or neutral molecules to be administered through the skin in an effective, noninvasive, patient-friendly manner. This chapter presents the basic concepts, mechanisms, and an analysis of electrotransport across the skin as a function of (i) electrical parameters, such as current density; (ii) formulation parameters, such as the influence of drug concentration, pH, and the presence of competing ions; and (iii) the delivery system.

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Authors and Affiliations

  1. Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasilia (UnB), Brasilia, DF, Brazil

    Taís Gratieri

  2. School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Geneva, Switzerland

    Yogeshvar N. Kalia

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  1. Taís Gratieri
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  2. Yogeshvar N. Kalia
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Correspondence to Taís Gratieri .

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Editors and Affiliations

  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Gratieri, T., Kalia, Y.N. (2017). Iontophoretic Transport Mechanisms and Factors Affecting Electrically Assisted Delivery. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53273-7_5

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  • DOI: https://doi.org/10.1007/978-3-662-53273-7_5

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