Abstract
Parathyroid hormone (PTH), when acutely infused, exerts potent cardiovascular action in man, such as: hypotension and positive chronotropic and inotropic effects. Parathyroid hormone-related protein (PTHrP) also induces hypotension and positive inotropic and chronotropic effect in the rat, and an influence of the adrenergic system on PTH and PTHrP secretion has been postulated. Therefore, the aim of the present study was to evaluate the effect of an acute norepinephrine (NE) infusion on blood pressure (BP), heart rate (HR), serum total (tCa) and ionized calcium (+ + Ca), cyclic 3′-5′ AMP (cAMP), immunoreactive intact [1–84] PTH and PTHrP levels in 5 healthy normotensive subjects, before and after a pretreatment with a beta-blocking agent, pindolol. NE, when acutely infused for 10 min, induced a significant increase in systolic and diastolic BP from the 10th to the 20th min, with a parallel significant decrease in HR, a significant increase in serum tCa and + + Ca and cAMP, with a parallel significant decrease in intact iPTH levels. Serum iPTHrP, during NE infusion, did not change from the baseline values. During pindolol, NE infusion did not induce any significant change in systolic and diastolic BP, in serum tCa and + + Ca, cAMP, intact iPTH and iPTHrP levels. Our results suggest that NE induces acute hypercalcemia which is not mediated by PTH nor PTHrP secretion. Hypercalcemic effect of NE seems to be mediated by adrenergic system, since it is abolished by a beta-blocking agent. Conversely, the significant decrease of serum intact iPTH is probably due to the hypercalcemic effect of NE. However, the involvement of other systems in the action of NE, like prostaglandin or RAA system, cannot be excluded.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Broadus AE, Mangin M, Insogna K et al.: Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N Engl J Med 319: 556–563, 1988
Juppner H, Abou-Samra AB, Uneno S et al.: The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptors on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 263: 8577–8582, 1988
Nissenson RA, Diep D, Strewler GJ et al.: Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. J Biol Chem 263: 12866–12870, 1988
Nickols GA, Nickols MA, Helwig J-J: Binding of parathyroid hormone and parathyroid hormone-related protein to vascular smooth muscle of rabbit renal microvessels. Endocrinology 126: 721–727, 1990
Pang PKT, Hong B-S, Yen L et al.: Parathyroid hormone: a specific potent vasodilator. Contr Nephrol 41: 137–141, 1984
Nickols GA, Nana AD, Nickols MA et al.: Hypotension and cardiac stimulation due to the parathyroid hormone-related protein, humoral hypercalcemia of malignancy factor. Endocrinology 125: 834–849, 1989
Kishimoto H, Tsumura K, Fujioka S et al.: Effects of parathyroid hormone-related protein on systemic and regional hemodynamics in conscious rats. A comparison with human parathyroid hormone. Contr Nephrol 90: 72–78, 1991
Joborn H, Hiemdahl P, Larsson PT et al.: Effects of prolonged adrenaline infusion and of mental stress on plasma minerals and parathyroid. Clin Physid 10: 37–53, 1990
Brown EM, Gardner DG, Windeck RA et al.: Beta-adrenergically stimulated adenosine 3′-5′-monophosphate release from dispersed parathyroid cells. J Clin Endocrinol Metab 48: 618–626, 1979
Brown EM, Hurwitz S, Woodard CJ et al.: Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. Endocrinology 100: 1073–1079, 1977
Armitage EK: Parathyrin (parathyroid hormone): metabolism and methods of assay. Clin Chem 32: 418–424, 1986
Shearing CH, Ashby JP, Hepburn DA et al.: Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglicemia in humans. Clin Endocrinology Metab 74: 1270–1276, 1992
Author information
Authors and Affiliations
About this article
Cite this article
Nami, R., Franci, M.B., Campagna, M.S. et al. Hypercalcemia induced by acute norepinephrine infusion is not mediated by PTH nor PTHrP secretion in man. J Bone Miner Metab 12 (Suppl 1), S193–S197 (1994). https://doi.org/10.1007/BF02375702
Issue Date:
DOI: https://doi.org/10.1007/BF02375702