Abstract
Synthetic human parathyroid hormone (PTH 1-34) was infused into seven healthy adults and their renal responsiveness examined. Blood and urine were collected at time zero and at 30 and 60 min after the infusion of PTH 1-34 (15µg in 50 ml of glucose solution infused in 10 min). A highly significant and parallel rise in both cyclic GMP and sodium excretion was found. No variation in blood atrial natriuretic factor concentration could be detected thereby suggesting that cyclic GMP is directly stimulated by PTH 1-34 and may play a role in the natriuretic effect of PTH.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Agus ZS, Gardner LB, Beck LH et al.: Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am J Physiol 224: 1143–1148, 1973
Gerzer R, Witzgall H, Tremblay J et al.: Rapid increase in plasma and urinary cGMP after bolus injection of atrial natriuretic factor in man. J Clin Endocrinol Metab 61: 1217–1219, 1985
Waldman SA, Rapoport RN, Murad F: Atrial natriuretic factor selectively particulate guanylate cyclase and elevates cyclic GMP in rat tissues. J Biol Chem 259: 14332–14333, 1984
Geiger H, Bahner U, Meissner M et al.: Parathyroid hormone modulates the release of atrial natriuretic peptide during acute volume expansion. Am J Nephrol 12: 259–264, 1992
Dousa TP, Barnes LD, Ong S-H et al.: Immunohistochemical localization of 3′:5′-cyclic AMP and 3′:5′-cyclic GMP in rat renal cortex: Effect of parathyroid hormone. Proc Natl Acad Sci USA 74: 3569–3573, 1977
Biddulph DM, Wrenn RW: Effects of parathyroid hormone on cyclic AMP, cyclic GMP, and efflux of calcium in isolated renal tubules. J Cyclic Nucleotide Res 3: 129–138, 1977
Puschett JB, McGowan J, Fragola J et al.: Difference between 1-84 parathyroid hormone and the 1-34 fragment on renal tubular calcium tranport in the dog. Miner Electrolyte Metab 10: 271–274, 1984
Roelen DL, Frölich M, Papapoulos SE: Renal responsiveness to synthetic human parathyroid hormone 1-38 in healthy subjects. Eur J Clin Invest 19: 311–315, 1989.
Tomlinson S, Mac Neil S, Brown BL: Calcium, cyclic AMP and hormone action. Clin Endocrinol 23: 595–610, 1985
Tremblay J, Gerzer R, Hamet P: Cyclic GMP in cell function. In: Greengard P, Robison GA (eds.) Advances in Second Messenger and Phosphoprotein Research. New York: Raven Press, pp. 319–383, 1988
Dunlay R, Hruska K: PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney. Am J Physiol 258: F223-F231, 1990
Hidaka H, Asano T: Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides. Proc Natl Acad Sci USA 74: 3657–3661, 1977
Takai Y, Kishimoto A, Kawahara Y et al.: Calcium and phosphatidylinositol turnover as signalling for transmembrane control of protein phosphorylation. In: Dumont J, Greengard P, Robison A (eds.) Advances in Cyclic Nucleotide Research. New York: Raven Press, pp. 301–313, 1981
Cantiello HF, Ausiello DA: Atrial natriuretic factor and cGMP inhibit amiloride-sensitive Na transport in the cultured renal epithelial cell line LLC-PKI. Biochem Biophys Res Commun 134: 852–860, 1986
Author information
Authors and Affiliations
About this article
Cite this article
Guillemant, J., Oberlin, F., Carayon, A. et al. Natriuresis and cyclic GMP stimulation by parathyroid hormone 1-34 in man. J Bone Miner Metab 12 (Suppl 1), S45–S48 (1994). https://doi.org/10.1007/BF02375674
Issue Date:
DOI: https://doi.org/10.1007/BF02375674