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Immunological aspects of bovine trypanosomiasis

IV. Patterns in the production of common antibodies

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Summary

Patterns of antibody production in relation to the presence or absence of trypanosomes and to drug treatment, were studied in 38 cattle. The animals were infected with one or more of the three groups of African pathogenic trypanosome. An indirect fluorescent antibody test was used. A stronger homologous antibody was noted. High levels of antibody were associated with the presence of circulating trypanosomes. Falling levels of antibody were associated with self-cure or chemotherapeutic treatment. Titre of homologous antibody was considered to be a valuable aid in ascertaining the stage of the disease, and may be useful in assessing the efficiency of chemotherapy in a herd.

Résumé

La production d'anticorps en relation avec la présence ou l'absence de trypanosomes et avec la chimiothérapie, a été étudiée chez 38 bovins. Les animaux étaient infectés avec un ou plus des trois groupes de trypanosomes africains pathogènes. Une réaction d'immuno-fluorescence indirecte a été employée. Les anticorps homologues donnaient une plus forte réaction. Des taux élevés d'anticorps étaient associées à la guérison spontanée ou au traitement chimiothérapeutique. Le titre d'anticorps homologués était considéré comme constituant une aide précieuse pour la détermination du stade de la maladie, et comme pouvant être utile pour évaluer l'efficacité de la chimiothérapie dans un troupeau.

Sumario

Los patrones en la producción de anticuerpos en relación a la presencia ó ausencia de tripanosomas y tratamiento con drogas, fueron estudiados en 38 cabezas de ganado. Los animales fueron infectados con uno ó mas de los tres grupos de tripanosomas africanos patogénicos. Se usó una prueba indirecta de anticuerpos fluorescentes (IFT). Se notó un anticuerpo homólogo mas fuerte. Niveles altos de anticuerpos fueron asociados con la presencia de trípanosomas circulantes. Niveles decrecientes de anticuerpos fueron asociados con la ‘autocura’ ó tratamiento quemoterapéutico. El título de anticuerpos homólogos fue considerado como una gran ayuda en la evaluación del estadió de la enfermedad y puede ser útil en la evaluación de la eficiencia de la quimioterapia en un hato.

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References

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Wilson, A.J., Cunningham, M.P. Immunological aspects of bovine trypanosomiasis. Trop Anim Health Prod 3, 133–139 (1971). https://doi.org/10.1007/BF02360742

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