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Participation of cholinergic structures of the prefrontal and inferotemporal cortex in the processes of visual recognition in monkeys

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Abstract

Monkeys performed a task of delayed visual differentiation of differently colored stimuli in behavioral experiments. The impulse activity of individual neurons of the prefrontal and inferotemporal cortex before and after the systemic administration of a blocker of M-cholinoreceptors, amyzil (0.8–1.0 mg/kg), was recorded simultaneously. Deterioration of the characteristics of recognition induced by amyzil was accompanied mainly by a significant increase in the activity of neurons of the prefrontal cortex which was dependant on the stage of recognition, and intensified with an increase in the delay interval. The impulse activity of the neurons of the inferotemporal cortex varied in the process without a regular pattern: at some stages of recognition it increased, at others it was inhibited. Amyzil induced a substantial decrease in the coefficients of cross correlation between the simultaneous respondent reactions of groups of neurons of the prefrontal and inferotemporal cortex. The results obtained point to the fact that the cholinergic structures of the inferotemporal and prefrontal cortex participate, at various stages of visual recognition in monkeys, in the formation of the dynamic functional systems which make their specific contribution to informational processes.

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Authors and Affiliations

  1. Laboratory of the Regulation of the Functions of Brain Neurons, I. P Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg

    K. N. Dudkin, V. K. Kruchinin & I. V. Chueva

Authors
  1. K. N. Dudkin
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  2. V. K. Kruchinin
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  3. I. V. Chueva
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Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 79, No. 2, pp. 31–42, February, 1993.

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Dudkin, K.N., Kruchinin, V.K. & Chueva, I.V. Participation of cholinergic structures of the prefrontal and inferotemporal cortex in the processes of visual recognition in monkeys. Neurosci Behav Physiol 24, 341–350 (1994). https://doi.org/10.1007/BF02360202

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  • DOI: https://doi.org/10.1007/BF02360202

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