Abstract
From the immunological standpoint,1–5 liver allografts are more resistant to hyperacute rejection than are other solid organ grafts. Therefore, until recently, donor/recipient blood type (ABO type), human leukocyte antigen (HLA) matching, and crossmatch tests were not considered in clinical liver transplantation. In this report, we demonstrated that: (a) crossing the ABO barrier must be avoided except in extreme emergency; (b) HLA class I matching effect on liver allografts is as acceptable as in kidney transplantation, although, with regard to the effect of Class II matches, there are remarkable differences depending on the patients' original disease; and (c) anti-donor lymphocytotoxic antibodies (positive crossmatch) adversely affect liver allograft survival rates.
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Starzl TE, Ishikawa M, Putnam CW, Porter KA, Picache R, Husberg BS, Halgrimson CS, Schroter G (1974) Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc 6:129–139
Starzl TE, Koep LJ, Halgrimson CG, Hood J, Schroter GP, Porter KA, Weil R (1979) Fifteen years of clinical liver transplantation. Gastroenterology 77:375–388
Iwatsuki S, Iwaki Y, Kano T, Klintmalm G, Koep LJ, Weil R, Starzl TE (1981) Successful transplantation from crossmatchpositive donors. Transplant Proc 13:286–288
Iwatsuki S, Rabin BS, Shaw BW Jr, Starzl TE (1984) Liver transplantation against T cell-positive crossmatches. Transplant Proc 16:1427–1429
Gordon RD, Fung J, Markus B, Fox I, Iwatsuki S, Esquival CO, Tzakis A, Todo S, Starzl TE (1986) The antibody crosmatch in liver transplantation. Surgery 100:705–715
Jamieson NV, Sundberg R, Lindell S, Claesson K, Moen J, Vreugdenhil PK, Wight DG, Southard JH, Belzer FO (1988) Preservation of the canine liver for 24–48 hours using simple cold storage with UW solution. Transplantation 26:517–522
Borel JF, Feurer C, Gubler HU, Stahelin H (1976) Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 6:468–475
Landsteiner K (1901) Ueber aggultinationserscheinungen normalen menschlichen blutes. Wien Klin Wochenschr 14: 1132–1134
Gordon RD, Iwatsuki S, Esquvel CO, Todo S, Makowka L, Tzakis A, Mash JW, Starzl TE (1987) Experience with primary liver transplantation across ABO blood groups. Transplant Proc 19:4575–4579
Iwaki Y, Ashizawa T, Cook D, Furui H, Takiff H, Mcdiarmid S, Terasaki PI, Colonna JO, Brems J, Busuttil RW (1988) ABO Matching in liver transplantation. Transplant Proc 20:564–565
White DJ, Gore SM, Barrose E, Calne RY (1987) The significance of ABO blood groups in liver transplant patients. Transplant Proc 19:4571–4574
Lo CM, Shked A, Busuttil RW (1994) Risk factors for liver transplantation across the ABO barrier. Transplantation 15: 543–547
Boudreaux JP, Hayes DH, Mizrahi S, Hussey J, Regenstein F, Balart L (1993) Successful liver/kidney transplantation across ABO incompatibility. Transplant Proc 25:1874
Kobayashi M, Yagihashi A, Noguchi K, Tanaka K, Takenaka T, Konno A, Terasawa K, Yoshida Y, Vanek M, Starzl TE, Iwaki Y (1994) Histocompatibility testing '91. Oxford University Press, London, pp 475–477
Gunson BK, Hathaway M, Buckels JA, Mayer AD, Elias E, McMaster P, Neuberger JM (1992) HLA matching in liver transplantation: A retrospective analysis. Transplant Proc 24: 2434–2435
University of Heidelberg Opelz G (ed) (1993) Collaborative Transplant Study. Newsletter 1
Yagihashi A, Kobayashi M, Noguchi K, Konno A, Yoshida Y, Terasawa K, Starzl TE, Iwaki Y (1992) HLA matching effect in liver transplantation. Transplant Proc 24:2432–2433
Kobayashi M, yagihashi A, Noguchi K, Terasawa K, Konno A, Hayashi S, Starzl TE, Iwaki Y (1993) HLA-DR matching effect in orthotopic liver transplantation under FK 506. Transplant Proc 25:228–229
Kissmeyer-Nielsen F, Olsen S, Patersen VP, Fjeldborg O (1966) Hyperacture rejection of kidney allograft, associated with preexisting humoral antibodies against donor cells. Lancet I:662–665
Patel R, Terasaki PI (1969) Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 280:735–739
Iwaki Y, Terasaki PI (1989) Primary nonfunction in human cadaver kidney transplantation: Evidence for hidden hyperacute rejection. Clin Transplantation 1:125–131
Takaya S, Duquesnoy R, Iwaki Y, Demetris J, Yagihashi A, Bronsther O, Iwatsuki S, Starzl TE (1991) Positive crossmatch in primary human liver allografts under cyclosporine or FK 506 therapy. Transplant Proc 23:396–399
Takaya S, Iwaki Y, Starzl, TE (1992) Liver transplantation in positive cytotoxic crossmatch cases using FK 506, high-dose steroids, and prostaglandin E1. Transplantation 54:927–929
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Ohashi, Y., Iwaki, Y. & Yagihashi, A. Effect of blood group matching on liver transplant survival rates. J Hep Bil Pancr Surg 2, 134–138 (1995). https://doi.org/10.1007/BF02348738
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DOI: https://doi.org/10.1007/BF02348738