Abstract
Thyroid tissue from a patient with Basedow's disease and immunopositive for HTLV-I was examined. Histopathological and immunohistochemical studies revealed that follicular-epithelial cells (FEC) had papillary projections reaching into the follicular lumina which were associated with diffuse T, but not B, lymphocyte infiltration and occasionally formed aggregations intermingled with T and B lymphocytes. Ultrastructurally, infiltrated lymphocytes possessing round or irregularly indented nuclei were detected in the capillary lumen, stroma and, also, FEC layers. The lymphocytes extended irregular processes, attached to long thin processes of FEC and infiltrated into FEC layers. Cocultivation of minced thyroid tissue with normal lymphocytes resulted in the establishment of a type-C virus-producing T-cell line.
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Ohtsuki, Y., Kubonishi, I., Furihata, M. et al. Immunohistochemical and ultrastructural studies of thyroid tissue from a patient with Basedow's disease and immunopositive for human T-lymphotropic virus type I (HTLV-I). Med Electron Microsc 27, 136–144 (1994). https://doi.org/10.1007/BF02348178
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DOI: https://doi.org/10.1007/BF02348178