Abstract
Enzyme-cytochemical studies were performed to clarify the pathogenesis of myocardial damage in endotoxemia. The reaction product of Ca++-ATPase was localized on the pinocytotic vesicles and plasma membrane of endothelial cells of capillaries and sarcolemma, sarcoplasmic reticulum and mitochondria of cardiomyocytes in control rats. However, the enzyme reaction product was reduced in amount and irregularly distributed on the plasma membrane, and on the increased number of pinocytotic vesicles of the endothelial cells of capillaries and the sarcolemma and sarcoplasmic reticulum of edematous cardiomyocytes after endotoxin injection. It is concluded that endotoxin induces structural changes and decreased activity in Ca++-ATPase in the vascular endothelium and myocytes of the heart.
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Fukui, M., Quao, Y., Kudou, M. et al. Ultrastructural localization ofcalcium dependent adenosine triphosphatase (ATPase) in the myocardium of endotoxin-administered rats. Med Electron Microsc 26, 151–155 (1993). https://doi.org/10.1007/BF02348041
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DOI: https://doi.org/10.1007/BF02348041