Abstract
Medial necrosis is a preceding lesion to angionecrosis which may cause hemorrhage and lacunar infarct. We morphometrically studied the loss of smooth muscle cells in the media of human cerebral arteries and examined the occurrences of vasospasm. Medial necrosis of hypertensive cases was significantly more severe than that of non-hypertensive cases (p<0.001). The outer media was significantly more vulnerable than the inner one (p<0.001). Medial necrosis in the perforating artery was slightly more severe than that of the cortical branches. Vasospasms were identified electron microscopically in 4 of 18 cases. These findings may satisfactorily explain the possibility of vasospasm as a cause of medial necrosis.
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Masawa, N., Suzuki, K. & Joshita, T. Morphometry of medial necrosis of human intracerebral arteries. Med Electron Microsc 26, 185–190 (1993). https://doi.org/10.1007/BF02347998
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DOI: https://doi.org/10.1007/BF02347998