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The Morpho-Functional Characteristics of Cerebral and Renal Arteries After Induced Arterial Hypertension in Rats Using Magnetic Resonance Imaging

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Abstract

The morpho-functional reorganization of regional vascular arteries is greatly altered after the induction of arterial hypertension (AH) in experimental rats. These changes can be examined using magnetic resonance imaging methods. In our experiment, induced AH caused arteriostenosis of cerebral arteries in two strains of rats—Wistar and OXYS (p < 0.05). In addition, we studied the changes in renal arteries in the same experiment. Compensatory vasodilatation was found in the extrarenal part of arteries. Arteriostenosis was detected in the intrarenal part of arteries, which was due to cytotoxic hypostasis of renal parenchyma. We proposed a cerebral vascular index and applied this index for precise analysis of changes in the studied arteries. This index is calculated as the ratio of the diameter of cerebral arteries to the diameter of renal arteries. The degree of differences in vasoconstriction between cerebral and renal arteries was established. Our results showed a moderate degree of differences in the vasoconstriction of cerebral arteries. In addition, the degree of differences in the vasoconstriction of intrarenal arteries revealed deeper vasoconstriction. These distinctions are 28.1% (p < 0.05) and 60.9% (p < 0.05) for Wistar and OXYS rats, respectively. Arterial morphometry revealed reduced sizes of all OXYS rat arteries compared with those of Wistar rat arteries. These pathological changes were associated with excessive stiffness (rigidity) of vascular walls due to accelerated aging. The accelerated aging of OXYS rat arteries led to a decrease in their vasodilatation potential and a decrease in the blood supply of cerebral and renal arteries. Comparative morphometry of the status of all arteries in both groups after AH revealed multiple specific changes in the remodeled arteries.

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References

  1. D. Ettehad, C. Emdin, A. Kiran, Lancet 5(387), 957–967 (2016)

    Article  Google Scholar 

  2. F. Viazzi, B. Bonino, R. Pontremoli, M. Muiesan, M. Salvetti, G. Schillaci, G. Pucci, A. Signori, J. Hypertens. 9(34), 1689–1697 (2016)

    Article  Google Scholar 

  3. Y. Vasyuk, S. Ivanova, E. Schkol’nik, Y. Kotovskaya, V. Milyagin, V. Oleynikov, Y. Orlova, A. Sumin, A. Baranov, S. Boytsov, A. Galyavitch, Z. Kabalava, Cardiovasc. Therapy Prevent. 15(2), 4–19 (2016)

    Article  Google Scholar 

  4. Zh Kabalava, Yu. Kotovskaya, A. Bogomaz, Ration. Pharmacotherap. Cardiol. 12(3), 317–324 (2016)

    Article  Google Scholar 

  5. E. Gogin, Terapeut. Arch. 4, 5–14 (2011)

    MathSciNet  Google Scholar 

  6. V. Moiseev, N. Mukhin, Zh Kabalava, S. Villevalde, M. Ehpremovtseva, L. Kozlovskaya, Yu. Kotovskaya, V. Fomin, S. Shalnova, F. Ageev, Cardiovasc. Therapy Prevent. 7(6), 1–20 (2008)

    Google Scholar 

  7. Y. Motin, A. Zsarikov, V. Bryuhanov, Morphology 5(1), C.33–C.37 (2011)

    Google Scholar 

  8. I. Agafonova, V. Kotelnikov, N. Kolosova, V. Stonik, Appl. Magn. Reson. 42(4), 487–497 (2010)

    Article  Google Scholar 

  9. N. Kolosova, N. Stefanova, S. Sergeeva, in Handbook of Cognitive Aging: Causes, Processes and Effects, ed. by Q. Gariépy, R. Ménard (Nova Science Publishers, Hauppage, N.Y. USA, 2009), pp. 47–82

    Google Scholar 

  10. N. Kolosova, T. Scheglova, T. Amstislavskaya, I. Loskutova, Bull. Exp. Biol. Med. 135(6), 593–596 (2003)

    Article  Google Scholar 

  11. T. Novgorodceva, M. Antonyuk, V. Kotelnikov, I. Agafonova. Patent of Russian Federation, No 2327228 June, 20, (2008)

  12. I. Agafonova, V. Kotelnikov, N. Kolosova, V. Stonik, Appl. Magn. Reson. 4(42), 487–489 (2012)

    Article  Google Scholar 

  13. I. Agafonova, N. Kolosova, V. Rasskazov, Pac. Med. J. 1, 104–107 (2012)

    Google Scholar 

  14. B. Geltser, V. Kotelnikov, I. Agafonova, P. Luk’yanov, M. Antonyuk, T. Novgorodtseva, Bull. Exp. Biol. Med. 144(1), 33–35 (2007)

    Article  Google Scholar 

  15. I. Agafonova, V. Kotelnikov, U. Eichoff, Appl. Magn. Reson. 45(5), 527–536 (2014)

    Article  Google Scholar 

  16. J. Booth, P. Muntner, M. Abdalla, K. Diaz, J. Schwartz, D. Shimbo, A. Viera, K. Reynolds, J. Hypertens. 2(34), 235–243 (2016)

    Article  Google Scholar 

  17. R. Oganov, O. Drapkina, Cardiovasc. Therapy Prevent. 15(4), 4–9 (2016)

    Article  Google Scholar 

Download references

Acknowledgements

The study was carried out on the equipment of the Collective Usage Center PIBOC FEBRAS, “Far East center of noninvasive radio-frequency diagnostics of biological objects” (FECNRFD). The research is partially supported by a grant from the Russian Scientific Fund (project No. 14-25-00037) and FEBRAS Grant No 15-I-5-006.

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Authors and Affiliations

  1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690022, Vladivostok, Russia

    Irina G. Agafonova & Valentin A. Stonik

  2. Far Eastern Branches of the State Research and Test Institute of Military Medicine of the Ministry of Defense of the Russian Federation, Vladivostok, Russia

    Vladimir N. Kotelnikov

  3. Pacific State University, Vladivostok, Russia

    Boris I. Geltcer

  4. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia

    Natalya G. Kolosova

Authors
  1. Irina G. Agafonova
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  2. Vladimir N. Kotelnikov
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  3. Boris I. Geltcer
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  4. Natalya G. Kolosova
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  5. Valentin A. Stonik
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Correspondence to Irina G. Agafonova.

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Agafonova, I.G., Kotelnikov, V.N., Geltcer, B.I. et al. The Morpho-Functional Characteristics of Cerebral and Renal Arteries After Induced Arterial Hypertension in Rats Using Magnetic Resonance Imaging. Appl Magn Reson 48, 911–919 (2017). https://doi.org/10.1007/s00723-017-0914-9

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  • DOI: https://doi.org/10.1007/s00723-017-0914-9

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