Abstract
A total of 36 male F344 rats was fed a diet containing 1% aspirin or 0.25% clofibrate for 1, 3 and 4 weeks. Hepatomegaly was more evident with aspirin than with clofibrate. The activity of magnesium dependent adenosine triphosphatase (Mg-ATPase) was localized on the limiting membrane of aspirin-induced peroxisomes, but it was much weaker than that in control and clofibrate-induced peroxisomes. Alteration in the ultrastructure of peroxisomes and mitochondria became more evident in Week 4 of the experiment than in Week 1. These ultrastructural changes also basically returned to normal conditions after one week withdrawal of the chemicals.
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Hakoi, K., Irimura, K. & Makita, T. Ultrastructural study of magnesium dependent adenosine triphosphatase (Mg-ATPase) activity in rat liver peroxisomes after administration of aspirin and clofibrate. Med Electron Microsc 26, 161–168 (1993). https://doi.org/10.1007/BF02347995
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DOI: https://doi.org/10.1007/BF02347995