Skip to main content
SpringerLink
Log in

Synthesis of doubly labeled polyacrylic acid with14C and3H

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Polyacrylic hydrogels were14C- and3H-labeled in three main steps. In the first one, the monomer as sodium salt was14C-labeled at the carboxyl group via the carbonation of vinylmagnesium bromide and [1-14C]acrylic acid was obtained, followed by labeling with tritium via isotopic exchange in heterogeneous catalysis. The monomer was purified and its radiochemical purity was analyzed using TLC. In the last step, the hydrogel was obtained through radiopolymerization of the doubly labeled monomer using a60Co source. The oligomers and unpolymerized monomers were eliminated from the hydrogel by swelling in water followed by dehydration with methanol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Roumanian Patent No. 110034 (23. 10. 1995), C. C. Ponta.

  2. E. A. Evans, Tritium and its Compounds, Pergamon Press, London, 1980.

    Google Scholar 

  3. A. T. Balaban, I. Galateanu, Gh. Georgescu, L. Simionescu, Labeled Compounds and Radiopharmaceuticals Applied in Nuclear Medicine, Acad. Bucuresti-Romania and John Wiley & Sons Ltd., 1986.

  4. C. I. Postolache, C. C. Ponta, C. Postolache, I. Mihalcea, I. Georgescu, Roum. Biotech. Lett, 2 (1997) 321.

    CAS  Google Scholar 

  5. W. J. Gensler, W. R. Kochler, J. Org. Chem., 27 (1962) 2754.

    CAS  Google Scholar 

  6. A. S. Vasilescu, C. C. Ponta, Progr. Colloid Polym. Sci., 102 (1996) 98.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CPR Department, National Institute for Physics and Nuclear Engineering-“Horia Hulubei”, PO Box MG-6, R-76900, Bucharest-Magurele, Romania

    C. I. Postolache & C. A. Simion

  2. Faculty of Chemistry, University of Bucharest, Bucharest, Carol 16, Romania

    I. I. Mihalcea

Authors
  1. C. I. Postolache
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. Simion
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. I. Mihalcea
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Postolache, C.I., Simion, C.A. & Mihalcea, I.I. Synthesis of doubly labeled polyacrylic acid with14C and3H. J Radioanal Nucl Chem 241, 33–35 (1999). https://doi.org/10.1007/BF02347286

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02347286

Keywords

Search

Navigation