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Diffuse intercapillary glomerulosclerosis in sucrose-fed rats

Glomérulosclérose intercapillaire diffuse chez des rats nourris au saccharose

Diffuse intercapilläre Glomérulosclerose bei mit Saccharose gefütterten Ratten

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Summary

In 8 rats fed with a high sucrose diet an impaired glucose tolerance curve was found. In 5 of those 8 animals diffuse intercapillary glomerulosclerosis of the kidneys was observed. No such changes were present in 10 age-matched, starch-fed rats.

Résumé

Chez 8 rats soumis à un régime riche en saccharose, on a constaté une courbe de tolérance diminuée au glucose. Chez 5 de ces 8 animaux une glomérulosclérose intercapillaire diffuse des reins a été observée. Aucune de ces modifications n'était présente chez 10 rats de même âge nourris avec de l'amidon.

Zusammenfassung

Bei 8 mit einer Saccharose-reichen Diät gefütterten Ratten ließ sich eine Verringerung der Glucosetoleranz nachweisen. 5 der 8 Tiere zeigten eine diffuse intercapilläre Glomerulosclerose der Nieren. Keine dieser Veränderungen war bei 10 gleichaltrigen, mit Stärke ernährten Ratten festzustellen.

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Authors and Affiliations

  1. Diabetes Unit and Department of Pathology, Hebrew University, Hadassah Medical School, Jerusalem, Israel

    A. M. Cohen & E. Rosenmann

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  1. A. M. Cohen
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  2. E. Rosenmann
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Supported by USDA Grant No. FG-IS-278.

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Cohen, A.M., Rosenmann, E. Diffuse intercapillary glomerulosclerosis in sucrose-fed rats. Diabetologia 7, 25–28 (1971). https://doi.org/10.1007/BF02346250

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  • DOI: https://doi.org/10.1007/BF02346250

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