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Force enhancement following stretch of activated muscle: Critical review and proposal for mechanisms

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Abstract

Force enhancement is an acknowledged and well-accepted mechanical property of skeletal-muscle contraction. It occurs in isometric, steady-state contractions that are preceded by stretch of the activated muscle. Force enhancement increases with increasing magnitudes of stretch, is long lasting, but can be abolished by deactivation of a muscle just long enough for force to drop to zero, and is associated with an increase in passive force. The mechanisms underlying force enhancement are not known. One of the classic mechanisms for force enhancement is reviewed, and a new mechanism that is based on an active and a passive component is introduced. The passive component of force enhancement is tentatively associated with the molecular spring titin, and the active component is associated with an increase in the proportion of attached cross-bridges caused by a decrease in the cross-bridge detachment rate. The review is completed by the proposal of some questions and selected experiments that would test the proposed mechanisms in a rigorous way.

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References

  • Abbott, B. C., andAubert, X. M. (1952): ‘The force exerted by active striated muscle during and after change of length’,J. Physiol.,117, pp. 77–86

    Google Scholar 

  • De Rutter, C. J., Didden, W. J. M., Jones, D. A., andDe Haan, A. (2000): ‘The force-velocity relationship of human adductor pollicis muscle during stretch and the effects of fatigue’,J. Physiol.,526, pp. 671–681

    Google Scholar 

  • Edman, K. A. P., Elzinga, G., andNoble, M. I. M. (1978): ‘Enhancement of mechanical performance by stretch during tetanic contractions of vertebrate skeletal muscle fibres’,J. Physiol.,281, pp. 139–155

    Google Scholar 

  • Edman, K. A. P., Elzinga, G., andNoble, M. I. M. (1982): ‘Residual force enhancement after stretch of contracting frog single muscle fibers’,J. Gen. Physiol.,80, pp. 769–784

    Article  Google Scholar 

  • Edman, K. A. P., andTsuchiya, T. (1996): ‘Strain of passive elements during force enhancement by stretch in frog muscle fibres’,J. Physiol.,490, pp. 191–205

    Google Scholar 

  • Finer, J. T., Simmons, R. M., andSpudich, J. A. (1994): ‘Single myosin molecule mechanics: piconewton forces and nanometre steps’,Nature,368, pp. 113–119

    Article  Google Scholar 

  • Forcinito, M., Epstein, M., andHerzog, W. (1998): ‘Can a rheological muscle model predict force depression/enhancement?’,J. Biomech.,31, pp. 1093–1099

    Article  Google Scholar 

  • Ford, L. E., Huxley, A. F., andSimmons, R. M. (1981): ‘The relation between stiffness and filament overlap in stimulated frog muscle fibres’,J. Physiol.,311, pp. 219–249

    Google Scholar 

  • Gordon, A. M., Huxley, A. F., andJulian, F. J. (1966): ‘The variation in isometric tension with sarcomere length in vertebrate muscle fibres’,J Physiol.,184, pp. 170–192

    Google Scholar 

  • Herzog, W. (1998): ‘History dependence of force production in skeletal muscle: a proposal for mechanisms’,J. Electromyogr. Kinesiol.,8, pp. 111–117

    Google Scholar 

  • Herzog, W., andLeonard, T. R. (2000): ‘The history dependence of force production in mammalian skeletal muscle following stretchshortening and shortening-stretch cycles’,J. Biomech.,33, pp. 531–542

    Google Scholar 

  • Herzog, W., andLeonard, T. R. (2002): ‘Force enhancement following stretching of skeletal muscle: a new mechanism’,J. Exp. Biol.,205, pp. 1275–1283

    Google Scholar 

  • Herzog, W., andRassier, D. (2002): ‘History dependence of skeletal muscle force production: a forgotten property’,J. Mech. Med. Biol.,2, pp. 347–358

    Google Scholar 

  • Herzog, W., Schachar, R., andLeonard, T. R. (2003): ‘Characterization of the passive component of force enhancement following active stretching of skeletal muscle’,J. Exp. Biol.,206, pp. 3634–3643

    Article  Google Scholar 

  • Hill, A. V. (1953): ‘The mechanics of active muscle’,Proc. Royal Soc. London,141, pp. 104–117

    Google Scholar 

  • Huxley, A. F., andNiedergerke, R. (1954): ‘Structural changes in muscle during contraction. Interference microscopy of living muscle fibres’,Nature,173, pp. 971–973

    Google Scholar 

  • Huxley, A. F. (1957: ‘Muscle structure and theories of contraction’,Prog. Biophys. Biophys. Chem.,7, pp. 255–318

    Google Scholar 

  • Huxley, A. F., andSimmons, R. M. (1971): ‘Proposed mechanism of force generation in striated muscle’,Nature,233, pp. 533–538

    Article  Google Scholar 

  • Huxley, H. E., andHansen, J. (1954): ‘Changes in cross-striations of muscle during contraction and stretch and their structural implications’,Nature,173, pp. 973–976

    Google Scholar 

  • Huxley, H. E. (1969): ‘The mechanism of muscular contraction’,Science,164, pp. 1356–1366

    Google Scholar 

  • Labeit, D., Watanabe, K., Witt, C., Fujita, H., Wu, Y., Lahmers, S., Funck, T., Labeit, S., andGranzier, H. L. (2003): ‘Calcium-dependent molecular spring elements in the giant protein titin’,Proc. Natl. Acad. Sci. USA,100, pp. 13716–13721

    Article  Google Scholar 

  • Lee, H. D., Herzog, W., andLeonard, T. R. (2001): ‘Effects of cyclic changes in muscle length on force production inin situ cat soleus’,J. Biomech.,34, pp. 979–987

    Google Scholar 

  • Lee, H. D., andHerzog, W. (2002): ‘Force enhancement following muscle stretch of electrically and voluntarily activated human adductor pollicis’,J. Physiol.,545, pp. 321–330

    Article  Google Scholar 

  • Molloy, J. E., Burns, J. E., Kendrick-Jones, J., Tregear, R. T., andWhite, D. C. S. (1995): ‘Movement and force produced by a single myosin head’,Nature,378, pp. 209–212

    Article  Google Scholar 

  • Morgan, D. L., Whitehead, N. P., Wise, A. K., Gregory, J. E., andProske, U. (2000): ‘Tension changes in the cat soleus muscle following slow stretch or shortening of the contracting muscle’,J. Physiol.,522, pp. 503–513

    Article  Google Scholar 

  • Noble, M. I. M. (1992): ‘Enhancement of mechanical performance of striated muscle by stretch during contraction’,Exp. Physiol.,77, pp. 539–552

    Google Scholar 

  • Peterson, D., Rassier, D., andHerzog, W. (2004): ‘Force enhancement in single skeletal muscle fibres on the ascending limb of the force-length relationship’,J. Exp. Biol.,207, pp. 2787–2791

    Article  Google Scholar 

  • Rassier, D. E., Herzog, W., andPollack, G. H. (2003a): ‘Dynamics of individual sarcomeres during and after stretch in activated single myofibrils’,Proc. Royal Soc. London B,270, pp. 1735–1740

    Google Scholar 

  • Rassier, D. E., Herzog, W., Wakeling, J., andSyme, D. (2003b): ‘Stretch-induced, steady-state force enhancement in single skeletal muscle fibers exceeds the isometric force at optimal fibre length’,J. Biomech.,36, pp. 1309–1316

    Article  Google Scholar 

  • Rassier, D. E., andHerzog, W. (2004): ‘Active force inhibition and stretch induced force enhancement in frog muscle treated with BDM’,J. Appl. Physiol.,96, pp. 419–427

    Article  Google Scholar 

  • Rayment, I., Holden, H. M., Whittaker, M., Yohn, C. B., Lorenz, M., Holmes, K. C., andMilligan, R. A. (1993): ‘Structure of the actin-myosin complex and its implications for muscle contraction’,Science,261, pp. 58–65

    Google Scholar 

  • Schachar, R., Herzog, W., andLeonard, T. R. (2002): ‘Force enhancement above the initial isometric force on the descending limb of the force-length relationship’,J. Biomech.,35, pp. 1299–1306

    Article  Google Scholar 

  • Schachar, R., Herzog, W., andLeonard, T. R. (2004): ‘The effects of muscle stretching and shortening on isometric forces on the descending limb of the force-length relationship’,J. Biomech.,37, pp. 917–926.

    Article  Google Scholar 

  • Sugi, H., andTsuchiya, T. (1988): ‘Stiffness changes during enhancement and deficit of isometric force by slow length changes in frog skeletal muscle fibres’,J. Physiol.,407, pp. 215–229

    Google Scholar 

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  1. Faculty of Kinesiology, University of Calgary, Calgary, Canada

    W. Herzog

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  1. W. Herzog
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Correspondence to W. Herzog.

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Herzog, W. Force enhancement following stretch of activated muscle: Critical review and proposal for mechanisms. Med. Biol. Eng. Comput. 43, 173–180 (2005). https://doi.org/10.1007/BF02345951

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  • DOI: https://doi.org/10.1007/BF02345951

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