Abstract
Bioimpedance spectroscopy is used to monitor the condition of the tissues of children staying in intensive care for the treatment of meningitis. The results are significant, with the angular frequency at maximum reactance lying between 1500 and 6400×103 rad s−1, whereas in a control group, this value does not exceed 900×103 rad s−1. The ratio between the specific conductance at zero and that at infinite frequency (this ratio is proportional to total body volume/volume of extracellular space) remains constant at 1.4 and equal to the ratio in the control group, despite infusions with physiological saline. The electrical parameters are associated with physiological ones and indicate that the membrane ‘capacitance’ decreases, as a result of the illness, from approximately 0.4 in the control group to 0.05 in the patient group. However, there is a time-delay between the onset of illness and the change in membrane capacitance. It is also found that the ratio between extracellular and intracellular specific conductivity in the group of patients and controls remains constant at approximately 4.3. The changes in the physiological and electrical parameters were compared with chemical parameters that were measured during the stay in intensive care.
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References
Bates, J. B., Chu, Y. T., andStribling, W. T. (1988) Surface topography and impedance of metal electrolyte interfaces.Phys. Rev. Lett.,70, pp. 627–630
Cole, K. S., andCole, R. H. (1941): ‘Dispersion and absorption in dielectrics. I. Alternating current characteristics’,J. Chem. Phys.,9, pp. 341–351
De Levie, R. (1989): ‘On the impedance of electrodes with rough interfaces’,J. Electroanal. Chem.,261, pp. 1–9
Foster, K. R., andSchwan, H. P. (1989): ‘Dielectric properties of tissues and biological materials,’Crit. Rev. Biomed. Eng.,17, p. 25
Hanai, T., Koizumi, M., andIrimajiri, A. (1975): ‘A method for determining the dielectric constant and the conductivity of membrane-bounded particles of biological membranes’,Biophys. Struct. Mech.,1, pp. 285–294
Hanai, T., andSekine, K. (1986): ‘Theory of dielectric relaxations due to the interfacial polarization for two-component suspensions of spheres’,Colloid Polymer Sci.,264, pp. 888–895
Irimajiri, A., Hanai, T., andInouye, A. (1975): ‘Dielectric properties of synaptosomes isolated from rat brain cortex’,Biophys. Struct. Mech.,1, pp. 273–283
Kaplan, T., andGray, L. J. (1985): ‘Effect of disorder on a fractal model for the AC response of a rough interface’,Phys. Rev. B.,32, (11), pp. 7360–7366
Liu, S. H. (1985): ‘Fractal model for the AC response of a rough interface’,Phys. Rev. Lett.,55, pp. 529–532
McAdams, E. T., andJossinet, J. (1996): ‘Problems in equivalent circuit modelling of the electrical properties of biological tissues’,Bioelectrochem. Bioenergetics,40, pp. 147–152
Nyikos, L., andPajkossy, T. (1985): ‘Fractal dimension and fractal power frequency—dependent impedance of blocking electrodes’,Electrochimica Acta,30, pp. 1533–1540
Pajkossy, T., andNyikos, L. (1989a): ‘Diffusion to fractal surfaces. II. Verification of theory’,Electrochimica Acta,34, pp. 171–179
Pajkossy, T., andNyikos, L. (1989b): ‘Diffusion to fractal surfaces. III. Linear sweep and cyclic voltammograms’,Electrochimica Acta,34 (2), pp. 181–186
Pauly, H., andSchwan, H. P. (1959): ‘Über die Impedanz einer Suspension von kugelförmingen Teilchen mit einer Schale’,Z. für Naturforschung,Teil B 14, pp. 125–131
Pauly, H., Pasker, L., andSchwan, H. P. (1960): ‘Electrical properties of mitochondrial membranes’,J. Biophys. Biochem. Cytol.,7, pp. 589–601
Pauly, H. (1963): ‘Über die elektrische Kapazität der Zellmembranen und die Leitfähigkeit des Zytoplasmas von Ehrlich-Aszitestumorzellen’,Biophysik,1, pp. 143–153
Schneider, W. (1975): ‘Theory of frequency dispersion of electrode polarization. Topology of networks with fractional power frequency dependence’,J. Phys. Chem.,79, pp. 127–136
Schwan, H. P. (1957): ‘Electrical properties of tissues and cell suspensions’ inLawrence, H. J., andTobias, C. A. (Eds): ‘Advances in biological and medicinal physics’, Vol. 5, pp. 148–209
Segal, K. R., Van Loan, M., Fitzgerald, P. I., andHodgdon, J. A. (1988): ‘Lean body mass estimation by bioelectrical impedance analysis. A four site cross validation study’,Am. J. Clin. Nutr.,47, pp. 7–14
van Kreel, B. K., Cox-Reyven, N. L., andSoeters, P. (1998): ‘Determination of total body water by multi-frequency bio-electric impedance: development of several models’,Med. Biol. Eng. Comput.,36, pp. 337–345
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van Kreel, B.K. Multi-frequency bioimpedance measurements of children in intensive care. Med. Biol. Eng. Comput. 39, 551–557 (2001). https://doi.org/10.1007/BF02345145
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DOI: https://doi.org/10.1007/BF02345145