Summary
An investigation was made into spontaneous mutation from bacteriophage-sensitivity to bacteriophage-resistance in P. pestis strains of different virulents. According to preliminary data, mutants resistant to bacteriophage appeared irrespective of the virulence of the initial strain and of the bacteriophage species used. Variants were isolated from the mutants, and by their chemical properties and capacity to grow on differential-diagnostic media and high pathogenicity for rabbits could be classed as causative agents of pseudotuberculosis.
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Literature Cited
G. N. Lenskaya, Variability of P. Pestis, Candidate's dissertation Saratov (1946).
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J. Lederberg and E. M. Lederberg, Bact. (1952),63, p. 399.
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Volosivets, A.I. Phage-resistant mutants of P. pestis and their properties. Bull Exp Biol Med 56, 1274–1277 (1963). https://doi.org/10.1007/BF02342838
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DOI: https://doi.org/10.1007/BF02342838