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Effect of mediators and anesthetics on the functional state of the superior cervical sympathetic ganglion

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

In experiments with perfusion of the superior cervical sympathetic ganglion of warm-blooded animals a study was made of the effect produced by mediators on the functional state of the ganglion and their modification by anesthetics (novocain, diethylaminoethanol, xylocaine). The anesthetics under study had some common properties —they inhibited ganglion excitation (provoked not only by acetylcholine, but also by histamine),even in doses hundreds of times below the mediator doses. The results obtained help to explain the wide therapeutic use of anesthetics in various pathological states by the fact that these agents possess an antimediator effect.

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Authors and Affiliations

  1. Physiological Laboratory, A. V. Vishnevskii Institute of Surgery of the AMN SSSR, Moscow

    T. V. Pravdich-Neminskaya

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  1. T. V. Pravdich-Neminskaya
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Pravdich-Neminskaya, T.V. Effect of mediators and anesthetics on the functional state of the superior cervical sympathetic ganglion. Bull Exp Biol Med 56, 1256–1260 (1963). https://doi.org/10.1007/BF02342833

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  • DOI: https://doi.org/10.1007/BF02342833

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