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The stimulating action of ACTH and related polypeptides on the spontaneous rhythm of isolated heart muscle cells in vitro

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

ACTH and α-MSH increase the rate of spontaneous pulsation of single isolated myoblasts cultured from the chick embryo heart. For synthetic β1-24 corticotropin the threshold concentration for this effect lies between .003 and .004 μg/ml of medium. The accelerator action of ACTH on cardiac cells is reduced when the ACTH is trented with periodate and boron hydride, and is torally inhibited by treatment of the cells with veratramine or dichloroisoproteronol.

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Authors and Affiliations

  1. Department for the Study of Blood Circulation, German Academy of Sciences, Berlin Bukh, German Democratic Republic

    A. Vollenberger & V. Galle

Authors
  1. A. Vollenberger
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  2. V. Galle
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Vollenberger, A., Galle, V. The stimulating action of ACTH and related polypeptides on the spontaneous rhythm of isolated heart muscle cells in vitro. Bull Exp Biol Med 56, 1187–1191 (1963). https://doi.org/10.1007/BF02342815

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  • DOI: https://doi.org/10.1007/BF02342815

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