Abstract
The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.
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References
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Clement, J.G. Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice. Arch Toxicol 66, 143–144 (1992). https://doi.org/10.1007/BF02342509
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DOI: https://doi.org/10.1007/BF02342509