Abstract
The pharmacokinetic and pharmacodynamic characteristics of a controlled-release (CR) formulation of trazodone were evaluated in healthy subjects who received acutely 150 mg and 75 mg of the CR trazodone and equal amounts of the conventional formulation on separate occasions. Plasma trazodone concentrations were measured by HPLC. The pharmacokinetic profile of CR trazodone was characterized by a slower increase in drug plasma levels and a lower and retarded peak plasma concentration without any modification in the total amount of trazodone absorbed over 24 hrs. The side effects were less severe and less frequent than with the conventional formulation.
Sommario
Le caratteristiche farmacocinetiche e farmacodinamiche di una formulazione di trazodone a rilascio controllato (CR) sono state studiate in volontari sani ai quali furono somministrati, in quattro differenti occasioni, 150 mg e 75 mg di trazodone CR e dosi equivalenti di trazodone in formulazione convenzionale. Le concentrazioni plasmatiche di trazodone furono misurate mediante HPLC. Rispetto alla formulazione convenzionale, il trazodone CR esibì un profilo farmacocinetico caratterizzato da un incremento più graduale dei livelli plasmatici e da una concentrazione massima più bassa e più ritar-data. Nessuna differenza nella quantità totale di farmaco assorbita nelle 24 ore fu osservata tra le due formulazioni. Dopo somministrazione del trazodone CR, gli effetti collaterali indesiderati furono meno severi e meno frequenti rispetto alla formulazione convenzionale.
Similar content being viewed by others
References
Abernethy D.R., Greenblatt D.J., Shader R.I.:Plasma levels of trazodone: methodology and applications. Pharmacology 28:42–46, 1984.
Ali C.J., Henry J.A.:Trazodone overdosage: experience over 5 years. Neuropsychobiology [Suppl. 1] 15:44–45, 1986.
Altamura A.C., Mauri M.C., Colacurcio F., et al.:Trazodone in late life depressive states: a double-blind multicentre study versus amitripty-line and mianserine. Psychopharmacology 95 (Supplement): 34–36, 1988.
Bayer A.J., Pathy M.S.J., Ankier S.I.:Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly. Br. J. Clin. Pharmacol. 16:371–376, 1983.
Bayer A.J., Pathy M.S.J., Cameron A. et al.:A comparative study of conventional and controlled-release formulations of trazodone in elderly depressed patients. Clin. Neuropharmacol. 12 [Suppl. 1]:S50-S55, 1989.
Brodgen R.N., Heel R.C., Speight T., Avery G.S.:Trazodone: a review of its pharmacological properties and therapeutic uses in depression and anxiety. Drugs 21:401–429, 1981.
Caccia S., Ballabio M., Fanelli R. et al.:Determination of plasma and brain concentrations of trazodone and its metabolite, 1-m-chlorophenyl-piperazine, by gas liquid chromatography. J. Chromatogr. Biomed. Appl. 210:311–318, 1981.
Feighner J.P., Boyer W.F.:Overview of U.S.A. controlled trials of trazodone in clinical depression. Psychopharmacology 95:S50-S53, 1988.
Gershon S., Newton R.:Lack of anticholinergic side effects with a new antidepressant-trazodone. J. Clin. Psychiatry 41:100–104, 1980.
Gershon S.:Comparative side-effects profile of trazodone and imipramine: special reference to a geriatric population. Psychopathology 17:39–50, 1984.
Hyslop D.K., Taylor D.P.:The interaction of trazodone with rat brain muscarinic cholinoceptors. Br. J. Pharmacol. 71:359–361, 1980.
Monteleone P., Gnocchi G., Delrio G.:Plasma trazodone concentrations and clinical response in elderly depressed patients: a preliminary study. J. Clin. Psychopharmacol. 9:284–287, 1989.
Monteleone P., Gnocchi G.:Evidence for a linear relationship between plasma trazodone levels and clinical response in depression in the elderly. Clin. Neuropharmacol. 13 [Suppl. 1]:S84-S89, 1990.
Prescott L.F., Proudfoot A.T.:Dangers of selfpoisoning with antidepressants. New directions in antidepressant therapy, an international review of the triazolopyridine derivatives. Royal Society of Medicine International Congress and Symposium series n. 46, Academic Press, London, 1981.
Spar J.E.:Plasma trazodone concentrations in elderly depressed inpatients: cardiac effects and short-term efficacy. J. Clin. Psychopharmacol. 7: 406–409, 1986.
Van de Merwe T., Silverstone T., Ankier S.I. et al.:A double-blind, non-crossover, placebo controlled between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology 17 (Supplement 2): 64–69, 1984.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Monteleone, P., Delrio, G. Pharmacokinetic and pharmacodynamic characteristics of a controlled-release formulation of trazodone versus the conventional formulation in healthy volunteers. Ital J Neuro Sci 14, 443–449 (1993). https://doi.org/10.1007/BF02339174
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02339174