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Circulating platelet aggregates: a chronic platelet activation in patients with transient ischaemic attacks

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Abstract

Platelet hyperaggregability was tested in 62 TIA patients by means of the formalin fixing principle of Wu and Hoak. Compared to age-matched controls, the platelet aggregates ratio (PAR) was reduced from 0.99±0.04 SD to 0.807±0.14 SD. This means a highly significant increase of circulating platelet aggregates (CPA) in untreated TIA patients, regardless of the interval sinche the last attack (from 2 days to 1 year). PAR was especially reduced in patients with abnormal angiography (expressing pronounced cerebral or diffuse ATS) and it was possibly affected by previous antiplatelet treatment with ASA.

Sommario

L'iperaggregabilità piastrinica è stata valutata in 62 pazienti affetti TIA mediante il metodo di Wu ed Hoak.

Il confronto con controlli di pari età ha evidenziato un significativo aumento degli aggregati piastrinici circolanti indipendentemente all'epoca dell'ultimo attacco.

I valori di PAR (paltelet aggregates ratio) sono risultati più ridotti nei pazienti con quadri angiografici patologici e più elevati nei malati con precedente terapia con ASA.

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Authors and Affiliations

  1. Università degli Studi di Roma 3a Cattedra Clinica Neurologica, Via Colli della Farnesina, 144-00194, Roma, Italia

    Marinis M. De, Prencipe M. & Paolucci S.

  2. Istituto Farmacologico Serono, Via Colli della Farnesina, 144-00194, Roma, Italia

    Fieschi C. & Falchetti R.

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  1. Marinis M. De
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  2. Fieschi C.
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  3. Prencipe M.
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  4. Falchetti R.
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  5. Paolucci S.
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Supported by the National Research Council, Special Project on Preventive Medicine.

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De Marinis, M., Fieschi, C., Prencipe, M. et al. Circulating platelet aggregates: a chronic platelet activation in patients with transient ischaemic attacks. Ital J Neuro Sci 1, 163–169 (1979). https://doi.org/10.1007/BF02335846

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