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Cerebrospinal fluid and peripheral blood T-lymphocyte subsets in multiple sclerosis: monoclonal antibody analysis and correlations with clinical activity

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Abstract

Enumeration of cerebrospinal fluid and peripheral blood T-lymphocyte subsets (T-total, T-helper and T-suppressor) was performed by monoclonal antibody technique in 18 patients with Multiple Sclerosis and in 4 patients with non-inflammatory neurological diseases. While no differences were observed in peripheral blood subsets among the various phases of the disease, a marked rise in cerebrospinal fluid helper-suppressor ratio was seen in acute relapses.

The results give further support to the concept of a strict compartimentalization in immune response abnormalities in Multiple Sclerosis patients.

Sommario

Sono state studiate con anticorpi monoclonali le sottopopolazioni linfocitarie (T-totali, T-helper e T-suppressor) ematiche e liquorali in 18 pazienti con sclerosi multipla e 4 con malattie neurologiche non infiammatorie. Non è stata trovata alcuna differenza del rapporto helper/suppressor nel sangue in varie fasi della malattia, mentre un aumento del rapporto helper/suppressor nel liquor è stato riscontrato nelle riesacerbazioni. I risultati confermano la compartimentalizzazione delle anomalie della risposta immunitaria nella sclerosi multipla.

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Authors and Affiliations

  1. Laboratorio Analisi. Istituto Neurologico «C. Besta», Via Celoria 11, 20133, Milano

    Salmaggi A., Bianchi G., Cerrato D., Lazzaroni M., Malesani L. & Nespolo A.

  2. Divisione Neurologica. Istituto Neurologico «C. Besta», Milano

    Corridori F., Mantia L. La & Milanese C.

Authors
  1. Salmaggi A.
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  2. Bianchi G.
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  3. Cerrato D.
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  4. Lazzaroni M.
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  5. Malesani L.
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  6. Nespolo A.
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  7. Corridori F.
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  8. Mantia L. La
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  9. Milanese C.
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Salmaggi, A., Bianchi, G., Cerrato, D. et al. Cerebrospinal fluid and peripheral blood T-lymphocyte subsets in multiple sclerosis: monoclonal antibody analysis and correlations with clinical activity. Ital J Neuro Sci 8, 327–330 (1987). https://doi.org/10.1007/BF02335734

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  • DOI: https://doi.org/10.1007/BF02335734

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