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The effect of an in situ-produced oil shale processing water on metabolism

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Abstract

The effects ofin situ-produced oil shale retort water on the metabolism of various substrates was studied bothin vivo andin vitro. The induction observed in rats was classified as Type I due to an increase in metabolism of hexobarbital and ethylmorphine without subsequent increases in zoxazolamine metabolism. The maximal absorption of the cytochrome-P-450-CO complex was observed to be 450 mμ, also consistent with Type I inducers. Cytochrome P-450 levels were also significantly increased over controls.

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Authors and Affiliations

  1. School of Pharmacy, University of Wyoming, 82071, Laramie, Wyoming

    K. F. Nelson, D. S. North, G. R. Payne, A. D. Anderson, R. E. Poulson & D. S. Farrier

  2. Laramie Energy Research Center, U.S. Energy Research and Development Administration, 82071, Laramie, Wyoming

    R. E. Poulson & D. S. Farrier

Authors
  1. K. F. Nelson
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  2. D. S. North
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  3. G. R. Payne
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  4. A. D. Anderson
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  5. R. E. Poulson
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  6. D. S. Farrier
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Additional information

This research was supported by a contract from U.S. ERDA, Laramie Energy Research Center, Laramie, Wyoming.

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Nelson, K.F., North, D.S., Payne, G.R. et al. The effect of an in situ-produced oil shale processing water on metabolism. Arch. Environ. Contam. Toxicol. 7, 273–281 (1978). https://doi.org/10.1007/BF02332055

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  • DOI: https://doi.org/10.1007/BF02332055

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