Skip to main content
SpringerLink
Log in

A simple optimization strategy based on Rs-minimum and information theory of chromatography

  • Originals
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

A simple optimization method based on the well-known Rs-minimum method and on the information theory of FUMI Φ is proposed. Resolution (Rs), peak area and height (or width) are the only parameters necessary for the calculation of the information Φ and information flow ϑ. The most precise analysis can be selected as the chromatogram having maximal ϑ. Mobile phase composition, column length, flow rate, detection wavelength, amount of internal standard, etc. can be optimized by this method.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. Jinno, K. Kawasaki, J. Chromatogr.298, 326 (1984).

    Article  CAS  Google Scholar 

  2. H. J. G. Debets, B. L. Bajema, D. A. Doornbos, Anal. Chim. Acta,151, 131 (1983).

    Article  CAS  Google Scholar 

  3. C. E. Goewie, J. Liquid. Chromatogr.,9, 1431 (1985).

    Google Scholar 

  4. J. C. Berridge, Anal. Chim. Acta,191, 243 (1986).

    Article  CAS  Google Scholar 

  5. P. J. Schoenmakers, J. Liquid Chromatogr.,10, 1865 (1987).

    CAS  Google Scholar 

  6. J. L. Glajch, J. J. Kirkland, J. M. Minor, J. Liquid Chromatogr.,10, 1727 (1987).

    CAS  Google Scholar 

  7. P. J. Schoenmakers, Optimization of Chromatographic Selectivity, Elsevier, Amsterdam, 1986.

    Google Scholar 

  8. Y. Hayashi, R. Matsuda, Fresenius, J., Anal Chem. submitted for publication.

  9. Y. Hayashi, R. Matsuda, A. Nakamura, Chromatographia,30, 85 (1990).

    CAS  Google Scholar 

  10. Y. Hayashi, R. Matsuda, Chromatographia,29, 446(1990).

    Article  CAS  Google Scholar 

  11. Y. Hayashi, S. Yoshioka, Y. Takeda, Anal. Sci.,5, 329 (1989).

    CAS  Google Scholar 

  12. Y. Hayashi, R. Matsuda, Anal. Chim. Acta,222, 313 (1989).

    Article  CAS  Google Scholar 

  13. Y. Hayashi, Anal. Sci.,6, 15 (1990).

    CAS  Google Scholar 

  14. R. Matsuda, Y. Hayashi, Chromatographia29, 371 (1990).

    Google Scholar 

  15. Y. Hayashi, R. Matsuda, Fresenius. J., Anal Chem. in press.

Download references

Author information

Authors and Affiliations

  1. National Institute of Hygienic Sciences, 18-1, Kamiyoga 1-chome, Setagaya, 158, Tokyo, Japan

    Y. Hayashi & R. Matsuda

Authors
  1. Y. Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Matsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayashi, Y., Matsuda, R. A simple optimization strategy based on Rs-minimum and information theory of chromatography. Chromatographia 30, 367–370 (1990). https://doi.org/10.1007/BF02328499

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02328499

Key words

Search

Navigation