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Cerebral necrosis following neutron radiation of an extracranial tumor

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Summary

Radiation necrosis of the brain is a rare complication of irradiation for extracranical tumors. We present a patient who emphasizes the potential hazard of neutron therapy, the sensitivity of magnetic resonance imaging (MRI) which may detect white matter changes prior to the development of clinical symptoms, the potential diagnostic value of 18F-fluorodeoxyglucose/positron emission tomography, and the importance of a combined surgical and medical approach for proper treatment.

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References

  1. Cohen L, Hendrickson FR, Kurup PDet al.: Clinical evaluation of neutron beam therapy: current results and prospects. Cancer 55:10–17, 1985

    CAS  PubMed  Google Scholar 

  2. Packer RJ, Zimmerman RA, Bilaniuk LT. Magnetic resonance imaging in the evaluation of treatment related central nervous system damage. Cancer 58:635–640, 1986

    CAS  PubMed  Google Scholar 

  3. Patronas NJ, Di Chiro G, Brooks SAet al. Work in progress: [18f]fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 144:85–88, 1982

    Google Scholar 

  4. Pistemaa DA. Densely ionizing particle radiation therapy. In: De Vita VT, Hellman S, Rosenberg SA (eds). Cancer: Principles and Practice of Oncology. JB Jippincott Company, Philadelphia, 1985, 2280–2292

    Google Scholar 

  5. Van der Kogel AJ, Sissingh HA, Zoetelief J. Effects of X rays and neutrons on repair and regeneration in the rat spinal cord. Int J Rad Oncol Biol Phys 8:2095–2097, 1982

    Google Scholar 

  6. Catterall M, Blake PR, Rampling RP: Fast neutron treatment as an alternative to radical surgery for malignant tumours of the facial area. Br Med J 289:1653–1655, 1984

    CAS  Google Scholar 

  7. Glass JP, Hwang TL, Leavens ME, Libshitz HI: Cerebral radiation necrosis following treatment of extracranial malignancies. Cancer 54:1966–1972, 1984

    CAS  PubMed  Google Scholar 

  8. Sheline GE. Radiotherapy of adult primary cerebral neoplasms. In: Walker ME (ed). Oncology of the Nervous System. Martinus Nijhoff, Boston, 1983, 223–245

    Google Scholar 

  9. Shaw CM, Sumi SM, Alvord EC, Gerdes AJ, Spence A, Parker RG. Fast neutron irradiation of glioblastoma multiforme. Neuropathological analysis. J Neurosurg 49:1–12, 1978

    CAS  PubMed  Google Scholar 

  10. Vogel FS, Pickering JE, Demyelinization induced in the brain of monkeys by means of fast neutrons: pathogenesis of the lesion and comparisons with the lesions of multiple sclerosis and Schilder's disease. J Exp Med 104:435–442, 1956

    Article  PubMed  Google Scholar 

  11. Manz HJ, Woolley PV, Ornitz RD. Delayed radiation necrosis of brainstem related to fast neutron beam irradiation. Cancer 44:473–479, 1979

    CAS  PubMed  Google Scholar 

  12. Mikhael MA: Radiation necrosis of the brain; correlation between computerized tomography, pathology, and dose distribution. J Comp Ass Tomog 2:71–80, 1978

    CAS  Google Scholar 

  13. Berger PC. Malignant astrocytic neoplasms: classification, pathologic anatomy, and response to treatment. Sem Oncol 13:16–26, 1986

    Google Scholar 

  14. Rizzoli HV, Pagnanelli DM. Treatment of delayed radionecrosis. J Neurosurg 60:589–594, 1984

    CAS  PubMed  Google Scholar 

  15. Edwards MS, Wilson CB: Treatment of radiation necrosis. In: Radiation Damage to the Nervous System. Gilbert HA, Kagan AR (eds). Raven Press, New York, 129–144, 1980

    Google Scholar 

  16. Rottenberg DA, Horten B, Kim JH, Posner JB: Progressive white matter destruction following irradiation of an extracranial neoplasm. Ann Neurol 8:76–78, 1980

    Article  CAS  PubMed  Google Scholar 

  17. Shaw PJ, Bates D. Conservative treatment of delayed cerebral radiation necrosis. J Neurol Neurosurg Psychiat 47:1338–1341, 1984

    CAS  PubMed  Google Scholar 

  18. Delattre JY, Rosenblum M, Mandell Let al.: Experimental radiation myelopathy: pathological and capillary permeability study and treatment with dexamethasone. Neurology 37:293, 1987

    Google Scholar 

  19. Caveness WF. Experimental observations: delayed necrosis in normal monkey brains. In: Radiation Damage to the Nervous System. Gilbert HA, Kagan AR (eds). Raven Press, New York, 1–38, 1980

    Google Scholar 

  20. Feigin I. Sequence of pathological changes in brain edema. In: Brain Edema. Klatzo I, Seitelberger F (eds) Springer Verlag, New York 1967, 615–631

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

    Jean -Yves Delattre, David A. Rottenberg & Jerome B. Posner

  2. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

    George Krol

  3. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

    Zvi Fuks

Authors
  1. Jean -Yves Delattre
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  2. Zvi Fuks
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  3. George Krol
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  4. David A. Rottenberg
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  5. Jerome B. Posner
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Delattre, J.Y., Fuks, Z., Krol, G. et al. Cerebral necrosis following neutron radiation of an extracranial tumor. J Neuro-Oncol 6, 113–117 (1988). https://doi.org/10.1007/BF02327386

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  • DOI: https://doi.org/10.1007/BF02327386

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