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Management of Cerebral Radiation Necrosis: A Retrospective Study of 12 Patients

  • Conference paper
Trends in Reconstructive Neurosurgery

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 124))

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References

  1. Alter BP (2002) Radiosensitivity in Fanconi’s anemia patients. Radiother Oncol : J Eur Soc Therape Radiol Oncol 62:345–347

    Article  Google Scholar 

  2. Barajas RF, Chang JS, Sneed PK, Segal MR, McDermott MW, Cha S (2009) Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following gamma knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol 30:367–372

    Article  CAS  PubMed  Google Scholar 

  3. Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U (2002) Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 25:1–53; discussion 54–55

    Article  PubMed  Google Scholar 

  4. Coderre JA, Morris GM, Micca PL, Hopewell JW, Verhagen I, Kleiboer BJ, van der Kogel AJ (2006) Late effects of radiation on the central nervous system: role of vascular endothelial damage and glial stem cell survival. Radiat Res 166:495–503

    Article  CAS  PubMed  Google Scholar 

  5. Dequesada IM, Quisling RG, Yachnis A, Friedman WA (2008) Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study. Neurosurgery 63:898–903; discussion 904

    Article  PubMed  Google Scholar 

  6. Dropcho EJ (2010) Neurotoxicity of radiation therapy. Neurol Clin 28:217–234

    Article  PubMed  Google Scholar 

  7. Eisele SC, Dietrich J (2015) Cerebral radiation necrosis: diagnostic challenge and clinical management. Rev Neurol 61:225–232

    CAS  PubMed  Google Scholar 

  8. Eyster EF, Nielsen SL, Sheline GE, Wilson CB (1974) Cerebral radiation necrosis simulating a brain tumor. Case report. J Neurosurg 40:267–271

    Article  CAS  PubMed  Google Scholar 

  9. Gatti RA (2001) The inherited basis of human radiosensitivity. Acta Oncol 40:702–711

    Article  CAS  PubMed  Google Scholar 

  10. Giglio P, Gilbert MR (2003) Cerebral radiation necrosis. Neurologist 9:180–188

    Article  PubMed  Google Scholar 

  11. Glass JP, Hwang TL, Leavens ME, Libshitz HI (1984) Cerebral radiation necrosis following treatment of extracranial malignancies. Cancer 54:1966–1972

    Article  CAS  PubMed  Google Scholar 

  12. Gutin PH, McDermott MW, Ross G, Chan PH, Chen SF, Levin KJ, Babuna O, Marton LJ (1990) Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system (CNS). Acta Neurochir Suppl 51:372–374

    CAS  PubMed  Google Scholar 

  13. Hopewell JW, Millar WT, Ang KK (2007) Toward improving the therapeutic ratio in stereotactic radiosurgery: selective modulation of the radiation responses of both normal tissues and tumor. J Neurosurg 107:84–93

    Article  PubMed  Google Scholar 

  14. Iwai Y, Yamanaka K, Oda J, Tsuyuguchi N, Ochi H (2001) Tracer accumulation in radiation necrosis of the brain after thallium-201 SPECT and [11C]methionine PET – case report. Neurol Med Chir 41:415–418

    Article  CAS  Google Scholar 

  15. Kano H, Kondziolka D, Zorro O, Lobato-Polo J, Flickinger JC, Lunsford LD (2009) The results of resection after stereotactic radiosurgery for brain metastases. J Neurosurg 111:825–831

    Article  PubMed  Google Scholar 

  16. Lorenzo ND, Nolletti A, Palma L (1978) Late cerebral radionecrosis. Surg Neurol 10:281–290

    CAS  PubMed  Google Scholar 

  17. Maldaun MV, Aguiar PH, Lang F, Suki D, Wildrick D, Sawaya R (2008) Radiosurgery in the treatment of brain metastases: critical review regarding complications. Neurosurg Rev 31:1–8; discussion 8–9

    Article  PubMed  Google Scholar 

  18. Morris JG, Grattan-Smith P, Panegyres PK, O’Neill P, Soo YS, Langlands AO (1994) Delayed cerebral radiation necrosis. Q J Med 87:119–129

    CAS  PubMed  Google Scholar 

  19. Pena LA, Fuks Z, Kolesnick RN (2000) Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer Res 60:321–327

    CAS  PubMed  Google Scholar 

  20. Roberts SA, Spreadborough AR, Bulman B, Barber JB, Evans DG, Scott D (1999) Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? Am J Hum Genet 65:784–794

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Ross DA, Sandler HM, Balter JM, Hayman JA, Archer PG, Auer DL (2002) Imaging changes after stereotactic radiosurgery of primary and secondary malignant brain tumors. J Neurooncol 56:175–181

    Article  PubMed  Google Scholar 

  22. Ruben JD, Dally M, Bailey M, Smith R, McLean CA, Fedele P (2006) Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys 65:499–508

    Article  PubMed  Google Scholar 

  23. Shehata MK, Young B, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni A, Mohiuddin M, Regine WF (2004) Stereotatic radiosurgery of 468 brain metastases < or =2 cm: implications for SRS dose and whole brain radiation therapy. Int J Radiat Oncol Biol Phys 59:87–93

    Article  PubMed  Google Scholar 

  24. Soffietti R, Sciolla R, Giordana MT, Vasario E, Schiffer D (1985) Delayed adverse effects after irradiation of gliomas: clinicopathological analysis. J Neurooncol 3:187–192

    Article  CAS  PubMed  Google Scholar 

  25. Sundgren PC (2009) MR spectroscopy in radiation injury. AJNR Am J Neuroradiol 30:1469–1476

    Article  CAS  PubMed  Google Scholar 

  26. Szeifert GT, Massager N, DeVriendt D, David P, De Smedt F, Rorive S, Salmon I, Brotchi J, Levivier M (2002) Observations of intracranial neoplasms treated with gamma knife radiosurgery. J Neurosurg 97:623–626

    PubMed  Google Scholar 

  27. Takeuchi J, Hanakita J, Abe M, Handa H (1976) Brain necrosis after repeated radiotherapy. Surg Neurol 5:89–93

    CAS  PubMed  Google Scholar 

  28. Taylor AM, Harnden DG, Arlett CF, Harcourt SA, Lehmann AR, Stevens S, Bridges BA (1975) Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258:427–429

    Article  CAS  PubMed  Google Scholar 

  29. Torcuator R, Zuniga R, Mohan YS, Rock J, Doyle T, Anderson J, Gutierrez J, Ryu S, Jain R, Rosenblum M, Mikkelsen T (2009) Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis. J Neurooncol 94:63–68

    Article  CAS  PubMed  Google Scholar 

  30. Truong MT, St Clair EG, Donahue BR, Rush SC, Miller DC, Formenti SC, Knopp EA, Han K, Golfinos JG (2006) Results of surgical resection for progression of brain metastases previously treated by gamma knife radiosurgery. Neurosurgery 59:86–97; discussion 86–97

    Article  PubMed  Google Scholar 

  31. Tsui EY, Chan JH, Leung TW, Yuen MK, Cheung YK, Luk SH, Tung SY (2000) Radionecrosis of the temporal lobe: dynamic susceptibility contrast MRI. Neuroradiology 42:149–152

    Article  CAS  PubMed  Google Scholar 

  32. van Dellen JR, Danziger A (1978) Failure of computerized tomography to differentiate between radiation necrosis and cerebral tumour. S Afr Med J 53:171–172

    PubMed  Google Scholar 

  33. West CM, Elliott RM, Burnet NG (2007) The genomics revolution and radiotherapy. Clin Oncol 19:470–480

    Article  CAS  Google Scholar 

  34. Wong ST, Loo KT, Yam KY, Hung WM, Fok KF, Yuen SC, Fong D (2010) Results of excision of cerebral radionecrosis: experience in patients treated with radiation therapy for nasopharyngeal carcinoma. J Neurosurg 113:293–300

    Article  PubMed  Google Scholar 

  35. Yoshii Y (2008) Pathological review of late cerebral radionecrosis. Brain Tumor Pathol 25:51–58

    Article  PubMed  Google Scholar 

  36. Yu JB, Schulder M, Knisely J (2012) Radiosurgical dose selection for brain metastasis. Prog Neurol Surg 25:139–147

    Article  PubMed  Google Scholar 

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Conflict of Interest Statement

The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, NO.1665 Shanghai Kongjiang Road, Yangpu, Shanghai, People’s Republic of China

    Chenlong Liao, Wenchuan Zhang, Min Yang, Wenxiang Zhong & Pengfei Liu

  2. Institute of Neurosurgery, Medical School, Catholic University of Rome, Rome, Italy

    Massimiliano Visocchi

Authors
  1. Chenlong Liao
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  2. Massimiliano Visocchi
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  3. Wenchuan Zhang
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  4. Min Yang
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  5. Wenxiang Zhong
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  6. Pengfei Liu
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Corresponding author

Correspondence to Wenchuan Zhang .

Editor information

Editors and Affiliations

  1. Institute of Neurosurgery Medical School, Catholic University of Rome, Rome, Italy

    Massimiliano Visocchi

  2. Dept. of Neurosurgery, Christian-Albrechts-University of Kiel, Kiel, Germany

    H. Maximilian Mehdorn

  3. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Yoichi Katayama

  4. Medical Faculty University of Münster, Münster, Germany

    Klaus R. H. von Wild

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Liao, C., Visocchi, M., Zhang, W., Yang, M., Zhong, W., Liu, P. (2017). Management of Cerebral Radiation Necrosis: A Retrospective Study of 12 Patients. In: Visocchi, M., Mehdorn, H.M., Katayama, Y., von Wild, K.R.H. (eds) Trends in Reconstructive Neurosurgery. Acta Neurochirurgica Supplement, vol 124. Springer, Cham. https://doi.org/10.1007/978-3-319-39546-3_30

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  • DOI: https://doi.org/10.1007/978-3-319-39546-3_30

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39545-6

  • Online ISBN: 978-3-319-39546-3

  • eBook Packages: MedicineMedicine (R0)

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