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Antigenic differences between a primary hamster lymphosarcoma and its liver metastases

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Summary

An antiserum was raised in rabbits against a primary metastasizing lymphosarcoma (ML) of the hamster. This was made tumor-specific by absorption with normal hamster tissue extracts. Immunoglobulin-G was prepared and tested for its cytotoxicity towards cells derived from the primary tumor and its liver metastases. The ML-specific IgG was found to be 2–5 times more cytotoxic for cells derived from the primary tumor compared to cells obtained from liver metastases.

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Author notes

  1. S. A. Shah

    Present address: Cancer Research Laboratory, Department of Chemical Engineering, Carnegie-Mellon University, 15213, Pittsburgh, Pa, USA

Authors and Affiliations

  1. Cancer Research Unit, University of Newcastle upon Tyne, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, England

    G. V. Sherbet, M. S. Lakshmi, G. P. Risely, S. A. Shah & M. E. Tindle

Authors
  1. G. V. Sherbet
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  2. M. S. Lakshmi
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  3. G. P. Risely
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  4. S. A. Shah
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  5. M. E. Tindle
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Additional information

Acknowledgments. The authors thank the North of England Cancer Research Campaign and the Manpower Services Commission for financial support.

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Sherbet, G.V., Lakshmi, M.S., Risely, G.P. et al. Antigenic differences between a primary hamster lymphosarcoma and its liver metastases. Experientia 38, 610–611 (1982). https://doi.org/10.1007/BF02327078

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  • DOI: https://doi.org/10.1007/BF02327078

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