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Voltage transients during ionic substitution in renal cortical tubules

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Summary

A voltage transient is described which is found during proximal tubular perfusion with impermeant cation or anion salt solutions in the rat. It was shown that the magnitude of transepithelial diffusion potentials depended on luminal hydrostatic pressure, suggesting that the observed transients might be the consequence of the enlargement of ionic pathways by tubular dilatation. Thus, when reporting PD values, care should be taken to define the pressure levels at which measurements were performed.

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Authors and Affiliations

  1. Department of Physiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, C.P. 4365, 01000, São Paulo, Brazil

    A. G. Lopes, G. B. de Mello & G. Malnic

Authors
  1. A. G. Lopes
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  2. G. B. de Mello
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  3. G. Malnic
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Additional information

Supported by Fund. de Amparo a Pesquisa do Estado de São Paulo, and FINEP.

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Lopes, A.G., de Mello, G.B. & Malnic, G. Voltage transients during ionic substitution in renal cortical tubules. Experientia 38, 588–590 (1982). https://doi.org/10.1007/BF02327064

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