Summary
MSH, like traumata to the eye, cause a permeability disturbance in rabbits, with protein leakage into the aqueous. The MSH effect was enormously increased by instillation of imidazole or pilocarpine. The MSH effect seems to engage a different mechanism than the prostaglandin-dependent action of other agents.
Similar content being viewed by others
Literatur
K. Wessely, Arch. J. Augenheilk.60, 97 (1908).
K. Dyster-Aas andC. E. T. Krakau, Invest. Ophthal.3, 127 (1964).
S. M. Podos, B. Becker andM. A. Kass, Prostaglandins3, 7 (1973).
M. B. Waitzman andC. D. King, Am. J. Physiol.212, 329 (1967).
J. R. Vane, Nature New Biol.231, 232 (1971).
A. H. Neufeld, L. M. Jampol andM. L. Sears, Nature, Lond.238, 158 (1972).
B. R. Beitch andK. E. Eakins, Br. J. Pharmac.37, 158 (1969).
H. K. Dyster-Aas, Acta ophthal., Copenh.43, 30 (1965).
H. K. Dyster-Aas andC. E. T. Krakau, Acta Univ. lund. Sectio II20 (1965).
K. Dyster-Aas andC. E. T. Krakau, Acta endocr.49, 166 (1965).
F. C. G. van de Veerdonk andE. Brouwer, Biochem. biophys. Res. Commun.52, 130 (1973).
M. Goldman andM. E. Hadley, Br. J. Pharmac.39, 160 (1970).
M. B. Waitzman andW. D. Woods, Expl. Eye Res.12, 99 (1971).
E. Bengtsson Invest. Opthal.,14, 306 (1975).
R. W. Butcher andE. N. Sutherland, J. biol. Chem.237, 1244 (1962).
P. Puig-Parellada, J. M. Planas andP. Puig-Muset, Ophthal. Res.7, 189 (1975).
H. A. Zink, S. M. Podos andB. Becker, Nature New Biol.245, 21 (1973).
The synthetic α-MSH was kindly put at our disposal by Ciba Ltd., Basel, Switzerland.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bengtsson, E., Krakau, C.E.T. Facilitation by imidazole of the aqueous flare response toα-melanocyte stimulating hormone. Experientia 31, 1054–1056 (1975). https://doi.org/10.1007/BF02326956
Issue Date:
DOI: https://doi.org/10.1007/BF02326956