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Synthesis of 6-Alkylthio-5-carbamoyl-3-cyano-4-phenyl-3,4-dihydropyridin-2(1H)-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Condensation of ethyl benzylidenecyanoacetate with thiocarbamoylacetamide in the presence of an equimolar amount of piperidine produces piperidinium 5-carbamoyl-3-cyano-2-oxo-4-phenyl-3,4-dihydropyridine-6(1H)-thiolate, which is then used in synthesis of the corresponding 6-alkylthiosubstituted 3,4-dihydropyridin-2(1H)-ones.

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Authors
  1. A. Krauze
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  2. G. Duburs
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Additional information

Dedicated to Professor Henk van der Plas on his 70th birthday.

Latvian Institute of Organic Synthesis, Riga LV-1006

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 506–509, April, 1999.

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Krauze, A., Duburs, G. Synthesis of 6-Alkylthio-5-carbamoyl-3-cyano-4-phenyl-3,4-dihydropyridin-2(1H)-ones. Chem Heterocycl Compd 35, 446–449 (1999). https://doi.org/10.1007/BF02319332

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  • DOI: https://doi.org/10.1007/BF02319332

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