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Structural features of muscimol, a potent GABAA receptor agonist, crystal structure and quantum chemicalab initio calculations

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Abstract

Muscimol, a constituent of the mushroomAmanita muscaria, is a semirigid analogue of the inhibitory neurotransmitter 4-aminobutyric acid (GABA). X-ray structure determinations and quantum chemicalab initio calculations (HF/6-31G*) have been carried out on the muscimol zwitterion. The solid-state conformations of the muscimol zwitterion are calculated to be 1.6–2.2 kcal/mol higher in energy than that of the calculated minimum energy structurein vacuo. A comparison of the calculated and experimental structures indicates that the hydrogen bonding network in the solid state significantly affects the geometry of the molecular structure. This conclusion is supported by results ofab initio calculations on binary complexes between muscimol and an ammonium ion and between muscimol and a methoxide anion, simulating observed hydrogen bonding in the crystal structures.

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Authors and Affiliations

  1. PharmaBiotec Research Center, Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark

    Lotte Brehm, Karla Frydenvang, Lene Merete Hansen, Per -Ola Norrby, Povl Krogsgaard-Larsen & Tommy Liljefors

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  1. Lotte Brehm
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  2. Karla Frydenvang
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  5. Povl Krogsgaard-Larsen
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Brehm, L., Frydenvang, K., Hansen, L.M. et al. Structural features of muscimol, a potent GABAA receptor agonist, crystal structure and quantum chemicalab initio calculations. Struct Chem 8, 443–451 (1997). https://doi.org/10.1007/BF02311703

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  • DOI: https://doi.org/10.1007/BF02311703

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