Skip to main content
SpringerLink
Log in

Solution conformation of tripeptides by NMR spectroscopy and force-field calculations

  • Published:
Structural Chemistry Aims and scope Submit manuscript

Abstract

The solution conformation of three linear tripeptides Boc-Ala-Val-Val-OMe1, Boc-Ala-Pro-Val-OMe2, and Boc-Ala-(D)Pro-Val-OMe3 was studied by NMR spectroscopy and accompanying force-field calculations. In one case,2, as preferred conformation theε-turnall trans conformer was found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wüthrich, K.NMR in Biological Research; Peptides and Proteins, North-Holland: Amsterdam, 1976.

    Google Scholar 

  2. Deber, C. M.; Glibowicka, M.; Wolley, G. A.Biopolymers 1990,29, 149.

    Article  CAS  Google Scholar 

  3. Smith, J. A.; Pease, L. G.CRC Crit. Rev. Biochem. 1980,8, 399.

    Google Scholar 

  4. Veis, A.; Nawrot, C. F.J. Am. Chem. Soc. 1970,92, 3910.

    Article  CAS  Google Scholar 

  5. Deslauriers, R.; Smith, I. C. P. InTopics in Carbon-13 NMR Spectroscopy; Levy, G. C., Ed.; Wiley-Interscience: New York, 1976; Vol. 2, p. 1.

    Google Scholar 

  6. Kessler, H.Angew. Chem. 1982,95, 509.

    Google Scholar 

  7. Bardi, R.; Piazzesi, A. M.; Tonioli, C.; Raj, P. A.; Ragothama, S.; Balaram, P.Int. J. Peptide Res. 1986,27, 229.

    CAS  Google Scholar 

  8. Paul, P. K. C.; Sukumar, M.; Bardi, R.; Piazzesi, A. M.; Valle, G.; Toniolo, C.; Balaram, P.J. Am. Chem. Soc. 1986,108, 6363.

    Article  CAS  Google Scholar 

  9. Bosch, R.; Jung, G.; Voges, K.-P.; Winter, W.Liebigs Ann. Chem. 184, 1117.

  10. Neubert, K.; Hartrodt, B.; Born, J.; Barth, A.CLB, Chem. Labor Biotech. 1991,42, 442.

    Google Scholar 

  11. SYBYL Molecular Modelling Software, TRIPOS Associates, St. Louis, MO.

Download references

Author information

Authors and Affiliations

  1. Institut für Organische Chemie und Strukturanalytik der Universität Potsdam, Am Neuen Palais 10, D-14415, Potsdam, Germany

    E. Kleinpeter

  2. Institut für Analytik und Umweltchemie der Martin-Luther Universität Halle-Wittenberg, Halle/Saale, Germany

    D. Ströhl & S. Peinze

Authors
  1. E. Kleinpeter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Ströhl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Peinze
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kleinpeter, E., Ströhl, D. & Peinze, S. Solution conformation of tripeptides by NMR spectroscopy and force-field calculations. Struct Chem 6, 377–382 (1995). https://doi.org/10.1007/BF02310179

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02310179

Key words

Search

Navigation