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Synthesis of N-acetyl derivatives of 5-and 6-ethoxy-2-methylthiobenzimidazole and their cardiotonic activity

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The regioselectivity of the N-acetylation of 5-and 6-ethoxy-2-methylthiobenzimidazole for various acetylating agents under various conditions has been investigated. The cardiotonic activity of the 1-acetyl-5-ethoxy-and 1-acetyl-6-ethoxy-2-methylthiobenzimidazoles synthesized and of their 5,6-diethoxy analog has been studied.

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Authors
  1. A. Brukshtus
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  2. A. Sirvidite
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  3. V. Garalene
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  4. L. Labanauskas
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Additional information

Vilnius University, Vilnius LT-2006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 765–771, June, 1997.

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Brukshtus, A., Sirvidite, A., Garalene, V. et al. Synthesis of N-acetyl derivatives of 5-and 6-ethoxy-2-methylthiobenzimidazole and their cardiotonic activity. Chem Heterocycl Compd 33, 665–671 (1997). https://doi.org/10.1007/BF02291796

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  • DOI: https://doi.org/10.1007/BF02291796

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