Abstract
4-Methylthio-2,3-dihydro-1H-1,5-benzodiazepine derivatives were prepared by alkylation of tetrahydro-1H-1,5-benzodiazepine-2-thiones with iodomethane or dimethyl sufate in the presence of base or using phase-transfer catalysis. The desired 4-acyl-hydrazino-2,3-dihydro-1H-1,5-benzodiazepines resulted from the reaction of iminothioethers with hydrazides.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
B. Puodžiünaité, L. Kosychova, R. Jančiené, and Z. Stumbrevičiùté, Monatsh. Chem.,128, 1275 (1997).
M.-P. Foloppe, I. Rault, S. Rault, and M. Robba, Heterocycles,36, 63 (1993).
G. C. Grossi, M. Di Braccio, G. Roma, M. Ghia, and G. Brambilla, Eur. J. Med. Chem.,28, 577 (1993).
M. G. Bock, R. M. Di Pardo, B. E. Evans, K. E. Rittle, R. M. Freidinger, R. S. L. Chang, and V. J. Lotti, J. Med. Chem.,31, 264 (1988).
Z. F. Solomko, P. A. Sharbatyan, A. A. Gaponov, and V. I. Avramenko, Khim. Geterostikl. Soedin., No. 3, 396 (1990).
F. Malik, M. Hassan, D. Rosenbaum, and H. Duddeck, Magn. Reson. Chem.,27, 391 (1989).
J. B. Press, C. M. Hofmann, N. H. Eudy, W. J. Fanshawe, I. P. Day, E. N. Greenblatt, and S. R. Safir, J. Med. Chem.,22, 725 (1979).
Additional information
Institute of Biochemistry, Vilnius 2600, Lithuania. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 368–372, March, 1998.
Rights and permissions
About this article
Cite this article
Puodžiünaité, B., Kosychova, L., Jančiené, R. et al. Synthsis and mild conversion of 1,5-benzodiazepine iminothioethers into hydrazides. Chem Heterocycl Compd 34, 334–338 (1998). https://doi.org/10.1007/BF02290727
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02290727